期刊文献+

调制多觉型伤害性感受器持续放电的体液因素 被引量:3

HUMORAL FACTORS IN THE MODULATION OF SUSTAINED DISCHARGES OF POLYMODAL NOCICEPTORS
下载PDF
导出
摘要 利用复合致痛剂引起大鼠皮肤多觉型伤害性感受器(PMN)持续放电的模型,发现刺激坐骨神经中枢端对 PMN 持续放电有显著的抑制或先易化后抑制效应。通过交叉灌流,刺激供血动物的坐骨神经也可对受血动物的 PMN 持续放电产生类似的效应。注射刺激坐骨神经动物的血清,可显著影响 PMN 的活动。大部分单位的抑制效应不被纳洛酮翻转。对吗啡耐受的动物,刺激坐骨神经仍可引起抑制效应。预先利血平化,则使刺激的易化效应基本取消。结果证实,躯体神经传入冲动诱发体液因素调制 PMN 的持续性活动。其中参与抑制效应的因子可能有阿片类与非阿片类,参与易化效应的因子可能是儿茶酚胺。 By using a model of sustained discharges of polymodal nociceptors(PMN)due to injection of a compound algogenic substance into the skin in anesthetized rats,it was found that stimulation of the sciatic nerve inhibited or facilitated at first andthen inhibited the PMN sustained discharges markedly.In a crossperfused prepa-ration,stimulation of the sciatic nerve of donor rat caused the similar effects on sus-tained discharges of PMN of the recipient rat.Injection of the animal serum afterstimulation of the sciatic nerve affected PMN activity obviously.The inhibitorycourse of most units could not be reversed by naloxone.In the animal toleranceto morphine,the effects of stimulation of the sciatic nerve could still be obtained.Preadministration of reserpine almost completcly abolished the facilitatory effect.The results indicate that sustained activity of PMN could be modulated by somehumoral factors due to somatic afferents.The inhibitory substances in the humoralfactor seem to be both opioid and nonopioid in nature.The facilitatory substanceseem to be a catecholamine.
出处 《生理学报》 CAS CSCD 北大核心 1990年第5期428-436,共9页 Acta Physiologica Sinica
基金 国家自然科学基金
关键词 伤害性感受器 坐骨神经 放电活动 polymodal nociceptors sciatic nerve humoral factors crossperfusion naloxone morphine tolerance reserpine
  • 相关文献

参考文献7

  • 1谢益宽,中国科学.B,1989年,8期,843页
  • 2姜树军,1989年
  • 3胡三觉,生理学报,1986年,38卷,232页
  • 4胡三觉,生理学报,1986年,40卷,437页
  • 5谢翠微,针刺研究,1981年,4卷,270页
  • 6邹冈,生理学报,1979年,31卷,371页
  • 7团体著者,针刺麻醉原理的探讨,1974年

同被引文献3

引证文献3

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部