摘要
目的 探讨别嘌呤醇所致重型药疹的可能机制及临床对策.方法 对我院收治的3例别嘌呤醇致重型药疹患者的临床资料进行回顾性分析.结果 2例男性患者经综合处理,分别于住院29天、35天病情好转而出院,1例病情危怠而转住某省级医院进一步救治,经随访,患者终救治无效死亡.结论 抗痛风药别嘌呤醇致重型药疹的发生机制非常复杂,可能与其化学结构有关,是机体对别嘌呤醇的一种超敏反应,也有非变态反应机制参与,足量皮质激素及抗组胺药应是首选治疗方案.
Objective the paper aims at discussing the possible pathogenesis and clinic treatment of the heavy drug eruption. Methods the authors made an analysis on 3 clinic cases in the hospital,in which some heavy drug eruptions occurred on patients taking allopurinol.Results the result was that there were 7 cases with drug eruption,3 of which erupted heavily. Among the three patients with heavy drug eruption,two were cured and one died when using corticotrophin and antihistamine for treatment.Conclusion the conclusion was that resulting from chemical mechanism of allopurinol,the pathogenesis of heavy drug eruption caused by the antigout medicine is very complicated and it is the body＇s allergic reaction to allopurinol. The preferred treatment is to use enough corticotrophin and antihistamine.
出处
《国际医药卫生导报》
2010年第18期2248-2250,共3页
International Medicine and Health Guidance News
关键词
别嘌呤醇
重型药疹
发病机制
临床对策
Allopurinol,Heavy drug eruption,Pathogenesis,Clinic treatment
