摘要
目的从流行病学角度探讨人类巨细胞病毒(HCMV)感染、高敏C反应蛋白(hs-CRP)及溶血磷脂酸(LPA)在急性冠脉综合征(ACS)发生过程中的作用。方法随机选取43例急性冠脉综合征(ACS)患者、20例稳定型心绞痛(SAP)患者及23例正常对照者,采用金标免疫层析法测定HCMV-IgG、HCMV-IgM抗体,胶乳增强免疫比浊散射法检测hs-CRP、比色法测定LPA浓度。结果 ACS患者HCMV-IgG阳性率、HCMV-IgM阳性率、hs-CRP、LPA均显著高于SAP及正常对照者(P<0.05);ACS患者中HCMV-IgM(+)患者hs-CRP、LPA均高于HCMV-IgM(-)者(P<0.05);ACS患者hs-CRP水平与LPA呈正相关(P<0.05)。结论急性HCMV感染或HCMV潜伏感染的活化与ACS的发生有关,其机制可能是HCMV通过激发和加重冠状动脉炎症反应而导致ACS的发生。
Objective To observe the effects of HCMV infection,hs-CRP and LPA on patients with acute coronary syndrome（ACS） from the perspective of epidemiology.Methods 43 cases of ACS patients,20 SA patients and 23 control individuals were selected at random.The gold standard immunochromatography method was used to determine HCMV-IgG,HCMV-IgM antibodies,latex enhanced immunoturbidimetric scattering method to examine the concentration of hs-CRP,and colorimetry to determine the concentration of LPA.Results The positive rates of HCMV-IgG and HCMV-IgM in ACS were significantly higher than those of SA and the control individuals,so did the concentrations of hs-CRP and LPA（all P〈0.05）.The concentrations of hs-CRP and LPA in HCMV IgM（＋） patients with ACS were higher than those in HCMV IgM（-） patients（all P〈0.05）.The levels of hs-CRP in ACS positively correlated with the LPA.Conclusions Acute HCMV infection or activation of HCMV latent infection are related to the occurrence of ACS.HCMV infection results in the coronary artery inflammation which causes the occurrence of ACS.
出处
《山东医药》
CAS
北大核心
2010年第33期13-15,共3页
Shandong Medical Journal
基金
衡水市科委基金资助项目(08003A)
