摘要
目的:比较复方苦参注射液联合DCF方案与单纯DCF方案治疗晚期胃癌的疗效及毒副反应。方法:将经病理组织学或细胞学和影像学确诊为晚期胃癌患者作为研究对象,均有可客观测量的病灶,分为复方苦参注射液联合DCF方案组(苦参组)25例及单纯DCF方案组(对照组)25例。每例患者至少接受治疗2周期以上。结果:苦参组25例获部分缓解(PR)12例,稳定(SD)10例,总有效率为48.0%;对照组25例获PR 11例,SD 9例,总有效率为44.0%;两组疗效比较无显著性差异(P>0.05)。苦参组白细胞减少的发生率、Ⅲ～Ⅳ度胃肠道反应和肝肾毒性显著少于对照组(P<0.05)。苦参组生活质量Karnofsky评分提高率52.00%,对照组提高率28.00%,两组差异有显著性(P<0.05)。结论:复方苦参注射液能够减少DCF方案化疗毒副作用,增加患者化疗耐受性,提高生活质量。
Objective： To observe and compare the efficacies and toxicities of compound matrine injection combined with DCF regimen（docetaxel＋cisplatin＋fluorouracil） and DCF regimen alone in the treatment of patients with advanced gastric carcinoma.Methods： Patients with advanced gastric carcinoma,diagnosed by histopathology,cytology and imaging,were divided into 2 groups.They were treated with DCF regimen alone（control group,n=25） or combination with compound matrine injection（matrine group,n=25）.Each patients received at least 2 cycles of the treatments.Results： In matrine group,the overall response rate was 48.0%（PR in 12 patients,SD in 10 patients,and PD in 3 patients）.In control group,the overall response rate was 44.0%（PR in 11 patients,SD in 9 patients and PD in 5 patients）.The difference in the overall response rates between the two groups was insignificant（P0.05）.The increase rate of Karnofsky score for the quality of life（52.0%） in matrine group was significantly higher than that（28.0%） in control group（P0.05）.The incidence rates of leucopenia,grade III～IV gastrointestinal reactions,hepatotoxicity and renal toxicity in matrine group were significantly lower than those in control group（P0.05）.Conclusion： Compound matrine injection can attenuate toxic effects of DCF chemotherapy,enhance patients＇ tolerance to chemotherapy and improve patients＇ quality of life.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2010年第17期1585-1588,共4页
Chinese Journal of New Drugs
关键词
复方苦参注射液
胃癌
化疗
compound matrine injection
gastric carcinoma
chemotherapy
