摘要
目的:观察维药芹菜根醇提物对肾性高血压大鼠血压的影响并探讨其降压机制。方法:建立两肾一夹(2K1C)肾性高血压模型,随机分为假手术组,模型组,阳性对照(卡托普利)组和维药芹菜根醇提物的高、中、低剂量组,按1次/d连续灌药16周,定期测定大鼠尾动脉收缩压和舒张压。末次给药后分离腹主动脉取血,测定超氧化物歧化酶(SOD)活力,丙二醛(MDA),血管紧张素Ⅱ(AngⅡ),内皮素(ET)含量。结果:维药芹菜根醇提物组的SOD活力明显升高,MDA含量明显降低,血浆ET含量明显降低,其中高剂量组血浆中Ang-Ⅱ含量明显降低。结论:维药芹菜根醇提物具有降低肾性高血压大鼠血压的作用。
Objective：To observe the effects of aqueous extract of alcohol of the roots of Apium graveolens on blood pressure and underlying the mechanisms in renal hypertension rats.Method：Two-kidney one clip（2K1C） renal hypertension rats were randomly divided into negative control group,model group,the positive control（Captopril,CAP） group and the roots of A.graveolens extract high,medium low-dose group and,the daily perfusion for 16 week at any time adjust the dose according to weight capacity,periodic determination of rat tail artery systolic and diastolic blood pressure.After the last administration,after separation of the abdominal aorta blood,take heart,left ventricular weight（LVW） / body weight（BW） ratio,superoxide dismutase（SOD） activity,malondialdehyde（MDA）,vascular tone factor Ⅱ（Ang Ⅱ）,endothelin（ET） content.Result：The roots of A.graveolens extract L treatment group was significantly higher SOD activity,lower MDA content and significantly decreased plasma ET levels.The roots of A.graveolens plasma high-dose group were significantly lower Ang Ⅱ levels.Conclusion：The roots of A.graveolens extract can depress blood pressure in rats with renal hypertension.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第11期101-103,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局留学回国人员科技活动择优资助课题(2003LHR19)
关键词
维药
芹菜根
肾性高血压
Uygur medicine
roots of Apium graveolens
renal hypertension
