摘要
目的观察呋塞米联合多巴胺微量泵入治疗顽固性心力衰竭的疗效、安全性及对患者血浆氨基末端脑钠肽前体(NT-proBNP)浓度的影响。方法将100例顽固性心力衰竭患者随机分为治疗组和对照组,对照组给予常规治疗,治疗组在对照组基础上加用呋塞米与多巴胺联合微量泵入,观察10 d,对两组的心功能改善、症状改善及心脏彩超进行对比,测6分钟步行试验(6MWT),并采用ELISA法对两组患者治疗前后血浆NT-proBNP进行测定。结果治疗组总有效率90%,显效率72%,治疗后左室射血分数(LVEF)显著高于对照组(P<0.05);6分钟步行距离增加;治疗组治疗后血浆NT-proBNP水平显著低于对照组(P<0.05)。结论呋塞米与多巴胺联合微量泵入在治疗顽固性心力衰竭中有重要意义,血浆NT-proBNP水平在心力衰竭治疗疗效评价中有较高敏感性。
Objective To detect the effect and safety of furosemide combined with dopaine by miorionfusion pump on treatment of refratory heart failure,and the effect on level of plasma NT-proBNP.Methods One hundred patients with refratory heart failure were divided into treatment group and control group randomly.The control group was treated with normal treatment.And treantment group was treated with furosemide and dopaine additionally based on the normal treatment.The treatment last 10 days.Comparison was done between the two groups,as the evaluation of improvement of heart function,improvement of signs of heart failure,the change of left ventricular ejecdtion fraction（LVEF） and left ventricular diastolic diameter（LVDd） by ultrasonography of heart as evalution index,6MWT was measured,and the level of plasma NT-proBNP was measured before and after treatment in each group.Results The total effective rate（90%）,total responsive rate（72%） and LVEF in treatment group were significantly higher than those in control group after treatment（P0.05）.6MWT was significantly longer in treatment group.And the plasma NT-proBNP level was significantly lower than that in control group（P0.05）.Conclusion Effect of combination of furosemide,dopaine in treatment of refratory heart failure is significant.Plasma NT-proBNP level has considerably high sensibility in evaluating treatment effect of heart failure.
出处
《临床医学》
CAS
2010年第9期13-14,共2页
Clinical Medicine
