摘要
目的探讨结节性甲状腺肿合并甲状腺微小乳头状癌中Galectin-3、CK19、HBME-1及CD56的表达及意义。方法采用免疫组化SP法检测10例结节性甲状腺肿合并甲状腺微小乳头状癌中Galectin-3、CK19、HBME-1和CD56的表达水平。结果 Galectin-3、CK19和HBME-1在甲状腺微小乳头状癌中均呈中至强阳性表达,而在结节性甲状腺肿中主要呈阴性或弱阳性表达。然而在10例甲状腺微小乳头状癌中有8例CD56的表达均为阴性,2例呈轻度阳性着色;周围结节性甲状腺肿组织9例均呈中至强阳性表达,仅1例呈轻度阳性着色。结论 Galectin-3、CK19、HBME-1及CD56联合检测将进一步提高甲状腺微小乳头状癌的准确性。
Purpose To explore the expression and significance of Galectin-3,CK19,HBME-1 and CD56 in nodular goiter combined with papillary thyroid microcarcinoma.Methods The immunohistochemical staining of Galectin-3,CK19,HBME-1 and CD56 was performed in ten patients with nodular goiter combined with papillary thyroid microcarcinoma.Results The moderate to strong staining for Galectin-3,CK19,HBME-1 was observed in papillary thyroid microcarcinoma but negative to mild in nodular goiter.Only one case of nodular goiter showed moderate staining for CK19.Eight cases of ten cases of papillary thyroid microcarcinoma,however,showed negative for CD56 staining and the two cases revealed positive.In the nodular goiter,nine cases showed moderate to strong staining for CD56 and only one case was mild staining.Conclusions The combined detection with Galectin-3,CK19,HBME-1 and CD56 will further improve the accuracy of papillary thyroid microcarcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2010年第4期425-428,共4页
Chinese Journal of Clinical and Experimental Pathology
