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cbl-b与肿瘤免疫

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摘要 cbl—b（casitas B cell lymphoma—b）是cbl家族中的一员，与cbl有79％的同源性，由于最早是从人乳腺癌中分离获得，故名cbl—b。沉默cbl—b后CD8＋T细胞可避开其激活时对共刺激信号CD28的依赖，细胞大量增殖并分泌大量的IL-2，同时也可以使T细胞对于TGF-β的抑制作用的敏感性降低。
作者 史振铎 王跃闽
机构地区 同济大学附属东方医院泌尿外科
出处 《同济大学学报（医学版）》 CAS 2010年第4期118-120,共3页 Journal of Tongji University(Medical Science)
基金 上海市浦东新区科委资助项目(PKJ2008-Y43)
关键词 cbl—b 肿瘤细胞 免疫
分类号 R730.51 [医药卫生—肿瘤]
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参考文献18

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二级参考文献9

  • 1陈巧英,李大金.CD4^+CD25^+调节性T细胞的生物学特性及功能[J].中国免疫学杂志,2007,23(1):89-92. 被引量：25
  • 2党珊,施秉银.Graves病患者CD4^+CD25^+调节性T细胞的变化[J].中华内分泌代谢杂志,2007,23(3):253-254. 被引量：7
  • 3Zorn E. CD4^+ CD25^+ regulatory T cells in human hematopoietic cell transplantation [ J ]. Seminars Cancer Biol,2006,16 : 150 - 159.
  • 4ErmannJ, Hoffmann P, EdingerM, et al. Only the CD62L^+ subpopulation of CD4^+ CD25^+ regulatory T cells protects from lethal acute GVHD[ J ]. Blood,2005, 105 : 2220 - 2226.
  • 5Taylor PA,Lees CJ,Blazar BR,et al. The infusion of ex vive activated and expanded CD4^+ CD25^+ immune regulatory cells inhibit graft-verus-host disease lethality [J]. Blood,2002,99(10) :3493 - 3499.
  • 6Zeiser R, Marks R, Bertz H, et al. Immunopathogenesis of acute graft-verus-host diseases : implications for novel preventive and therapeutic strategies [ J ]. Annals Hematol,2004,83 (9): 558 - 559.
  • 7Taylor PA, Panoskaltsis MA, Swedin JM, et al. L- Selection (hi) but not the L-selection(lo) CD4^+ CD25^+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection [ J ]. Blood, 2004, 104 ( 12 ) : 3804 -3812.
  • 8Godfrey WR, Spoden DJ, Ge YG, et al. Cord blood CD4^+ CD25^+ -derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function [ J ]. Blood, 2004,105 ( 2 ) : 750 - 758.
  • 9Orabona C, Grohmann U, Belladonna ML, et al. CD28 induce immunostimulatory signals in dendritic cells via CD80 and CD86 [ J ]. Nature Immunol, 2004,5 ( 11 ) : 1134 - 1142.

共引文献4

同济大学学报（医学版）
2010年 第4期

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