摘要
分化抗原簇69（cluster of differentiation69,CD69）于1981年发现,早期被称为活化诱导分子（activation inducer molecule,AIM）,早期活化抗原-1（earlyactivationantigen-1，EA-1）等，是C-型凝集素受体家族的成员，CD69基因属于自然杀伤细胞（natural killer cell，NK细胞）信号转导基因复合体家族，在细胞的生物功能调节中起着重要的信号转导作用。
CD69,a member of C type lectin superfamily and NK cell gene family,plays important roles in signal transduction in the regulation of cellular functions. Previous studies demonstrate that CD69 has a vital role in cell activation and CD69 is used as a marker of cell activation because of its early expression in activated cells. CD69 is also the costimulatory signal for cell activation,proliferation and differentiation. Furthermore,recent studies show the close association between CD69 and apoptosis. CD69 mediates apoptosis selectively in activated cells,mainly in activated eosinophils and monocytes. Using CD69 as an apoptotic inducer in certain cells may have good result and less side effect. This article tries provide a brief summary of the dual immunoregulatory effects of CD69 on cell activation and apoptosis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2010年第9期1859-1862,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No30600266)
浙江省教育厅科研计划资助项目(No20061402)
