期刊文献+

伊马替尼治疗胃肠道间质瘤58例疗效分析 被引量:2

Analysis of Gastrointestinal Stromal Tumors Treated by Imatinib in 58 Patients
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摘要 目的探讨伊马替尼治疗胃肠道间质瘤的疗效。方法对长海医院2007年1月~2009年9月收治的58例经伊马替尼治疗的胃肠道间质瘤病人的临床资料进行回顾性分析。结果局限可切除胃肠道间质瘤患者36例,无一例复发或转移。22例广泛期胃肠道间质瘤患者中,服药3个月CT评价:完全缓解0例(0%),部分缓解11例(50%),稳定11例(50%),进展0例(0%),临床获益率100%;1年生存率为95.5%。结论伊马替尼治疗局限期和广泛期胃肠道间质瘤都具有较好的临床获益。 Objective To investigate the effects of imatinib on gastrointestinal stromal tumor. Methods From January 2007 to September 2009, 58 Imatinib - treated patients with gastrointestinal stromal tumors were analyzed retrospectively. Results In 36 eases in local stage, no recurrence or metastasis was found. After Imatinib being used for 3 months, outcome of patients in extensive stage were CR 0, PR 50% , SD 50% and PD 0. The 1 - year overall survival rate was 100%. Conclusion Imatinib is effective for gastrointestinal stromal tumors both in local stage and extensive stage.
出处 《医学研究杂志》 2010年第9期94-96,共3页 Journal of Medical Research
关键词 胃肠间质瘤 伊马替尼 治疗 Gastrointestinal stromal tumor Imatinib Treatment
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参考文献10

  • 1E isenburg BL,Judson I. Surgery and imatinib in the management of GIST: Emerging approaches to adjuvant and neoadjuvant therapy. Annals of Surgical Oneoloy, 2004,11 (5) :465 - 475.
  • 2Miettinen M, Lasota J. Gastrointestinal stromal tumors definition, clinical,histological,immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch ,2001,438 ( 1 ) : 1.
  • 3刘岗,郭琳,王强.胃肠道间质瘤78例临床分析[J].胃肠病学,2009,14(3):171-173. 被引量:4
  • 4Rankin C, Yon Mehren M, Blanke C, et al. Dose efect of imatinib in patients wi th metastatic GIST- Phase Ⅲ Sarcoma Group Study S0033. Proc Am Soc Clin Oncol, 2004,23:815.
  • 5Kikuchi H, Yamamoto M, Hiramatsu Y, et al. Effect of loss of heterozygosity of the c - kit gene on prognosis after hepatectomy for metastatic liver gastrointestinM stromal tumors. Cancer Sci ,2007 ,98 ( 11 ) : 1734 - 1739.
  • 6Buchdunger E, Cioffi CL, Law N,et al. Abl protein- tyrosine kinase inhibitor STI 571 inhibits in vitro signal transduction medicated by c - kit and platelet - derived growth factor receptors. J Pharmacol Exp Ther,2000,295 ( 1 ) :139 - 145.
  • 7Demetri GD,van Oosterom AT, Garrett CR,et al. Eficacy and safety of sunitinlb in patienls with advanced gastroinlestinal stromal turnout after failure of imatinib:a randomised controlled trial. Lancet,2006,368 (9544) :1329 - 1338.
  • 8王海江,杨新辉.甲磺酸伊马替尼治疗手术后复发和/或转移的胃肠道间质瘤的疗效分析[J].新疆医科大学学报,2008,31(12):1716-1717. 被引量:1
  • 9Mussi C, Ronellenfitsch U , Jakob J, et al. Post - imatinib surgery in advanced/metastatic GIST: is it worthwhile in all patients? Annals of Oncology, 2009,10 : 1093.
  • 10Eisenberg BL, Harris J, Blanke CD,et al. Phase Ⅱ trial of neoadjurant/adjuvant imatinib mesylatc (IM) for advanced primary and meta-static/recurrent operable gastrointestinal stromal tumor (GIST) : early results of RTOG 0132/ACRIN 6665. J Surg Oncol, 2009,99( 1 ) :42 -47.

二级参考文献21

  • 1Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol, 1983, 7 (6): 507-519.
  • 2Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol, 2002, 33 (5): 459-465.
  • 3Pisanu A, Ambu R, Uccheddu A. Uncommitted gastrointestinal stromal tumour. Case report. G Chir, 2001, 22 (6-7): 217-221.
  • 4Sandrasegaran K, Rajesh A, Rushing DA, et al. Gastrointestinal stromal tumors: CT and MRI findings. Eur Radiol, 2005, 15 (7): 1407-1414.
  • 5Ando N, Goto H, Niwa Y, et al. The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with immunohistochemical analysis. Gastrointest Endosc, 2002, 55 (1): 37-43.
  • 6Neuhaus S J, Clark MA, Hayes AJ, et al. Surgery for gastrointestinal stromal turnout in the post-imatinib era. ANZ J Surg, 2005, 75 (3): 165-172.
  • 7Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med, 2001, 344 (14): 1052-1056.
  • 8[1]Mazur MT,Clark HB.Gastrointestinal stromal tumours:reap-praisal of histogenesis[J].Am J Surg Pathol,1983,7:507-519.
  • 9[2]Duffaud F,Blay JY.Gastrointestinal stromal tumors:biology and treatment[J].Oncology,2003,65:187-197.
  • 10[3]Joensuu H,Fletcher C,Dimitrijevic S,et al.Management of malignant gastrointestinal stromal tumours[J].Lancet Oncol,2002,3:655-664.

共引文献3

同被引文献11

  • 1郑斌,危晴岚,刘茂柏.甲磺酸伊马替尼临床研究概况[J].海峡药学,2006,18(6):78-80. 被引量:12
  • 2Reichardta P, Hogendoornb CW,Tamborinic E, et al. Gastrointestinal stromal tumors I: pathology, pathobiology, primary therapy, and surgi- cal issues[ J]. Semin 0ncol,2009,36(4) :290 - 301.
  • 3Huang H,Liu YX,Zhan ZL,et al. Different sites and prognoses of gas- trointestinal stromal tumorsof the stomach: report of 187 cases [ J]. World J Surg,2010,34 : 1523 - 1533.
  • 4Joensuu H, Vehtari A, Riihimfiki J,et al. Risk of recurrence of gastro- intestinal stromal turnout after surgery : an analysls of pooled populatlon - based cohorts [ J ]. Lancet 0ncol,2012,13 ( 3 ) :265 - 274.
  • 5Chen YH, Liu KH, Yeh CN,et al. Laparoscopic resection of gastroin- testinal stromal tumors: safe, efficient, and comparable oncologic out- comes[J]. J Laparoendosc Adv Surg Tech A,2012,22(8) : 758 -763.
  • 6Dematteo R, Ballman KV, Antonescu CR, et al. Adjuvant imatinib mesylate after resection of localized, primary gastrointestinal stromal tumours : a randomised, doable - blind, placebo - controlled trial [J]. Lancet, 2009,373 (9669) : 1097 - 1104.
  • 7Corless CL, Ballman KV, Antonesc UC, st al, Relation of tumor path- ologic and molecular features to outcome after surgical resection of lo- calized primary gastrointestinal stromal tumor(GIST) : result of the in- tergroup phase III trial ACOSOC Z9001 [ J]. J Clin Oncol, 2010,28 ( suppl 15 ) : 10006.
  • 8刘海燕,崔艳,严拯宇.HPLC法测定盐酸羟嗪含量及有关物质[J].海峡药学,2009,21(12):59-61. 被引量:4
  • 9CAO Hui,ZHANG Yun,WANG Ming,SHEN Dan-ping,SHENG Zhi-yong,NI Xing-zhi,WU Zhi-yong,LIU Qiang,SHEN Yan-ying,SONG Yan-yan.Prognostic analysis of patients with gastrointestinal stromal tumors: a single unit experience with surgical treatment of primary disease[J].Chinese Medical Journal,2010(2):131-136. 被引量:20
  • 10程芳,张晓玲,严拯宇.HPLC法检查盐酸多塞平有关物质[J].海峡药学,2011,23(1):45-47. 被引量:1

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