摘要
脊椎动物听觉皮层下该团的功能性研究被揭示时尚很有限,(?)报导用神经生化的方法,研究了大白鼠中枢神经系统中,与听觉有关的下丘,桥脑比全脑MAO-B monoamme oxidase E C 1.23.4的活性,及在药物作用下的变化,以探讨单胺类神经递质在支因下听觉中枢作用的可能性,结果表明:1.与听觉有关的下丘,桥脑MAO-B活性明显高于全脑的平均水平.2.药物制首乌对下丘、桥脑及全脑的MAO-B活性均有显著的抑制作用,结果提示:下丘、桥脑MAO-B对单胺类神经递质的氧化脱氨作用高于全脑的平均水平,单胺类神经递质有可能作为皮层下听觉中枢的神经递质参与听觉的活动.
The function of auditory subcortical nuclei of vertebrate and their mechanism are rarely exposed. This paper reports a work done for probing the possible action of monoamine neurotransmitter in auditory subcortical nuclei. The work investigated the MAO-B (Monoamine Oxidase E. C. 1.2.3.4) activities of inferior colliculus, pons which is related to auditory activity and whole brain in rat and the change of MAO - B activity by drug. A biochemical method was used in the work. The results indicate that:(1) The average MAO-B activities of inferior colliculus and pons were significantly higher than that of the whole brain.( 2) Medicine Polygonum multiflorum Thunb had a significant inhibitory effect on the MAO - B activities of the inferior colliculus, pons and whole braiaThe result suggested that the MAO-B of inferior colliculus and pons had stronger effect of oxidizing deamination on monoamine than that of the whole brain, the monoamine, therefore, probably as a neurotransmitter of auditory subcortical nuclei took part in the auditory activities.
出处
《生物物理学报》
CAS
CSCD
北大核心
1990年第4期530-534,共5页
Acta Biophysica Sinica
基金
国家自然科学基金资助项目
