摘要
线粒体是细胞中能量储存和供给的场所,也是动物细胞核外唯一含有遗传效应物质的细胞器。线粒体DNA自身的结构特点使其容易受到损伤,其独立的复制表达系统往往可成为外源物质攻击的靶点。很多药物的不良反应均与mtDNA损伤有关。以抗逆转录病毒药物、抗肿瘤药物和抗生素为例,综述线粒体DNA相关药物不良反应及其相关机制,并对防治方法进行了探讨。
Mitochondrium, the place where the energy is stored and supplied, is the unique organelle which also has the genetic material outside the cellular nucleus of animals. Mitoehondrial DNA（mtDNA） is vulnerable to injury, and its independent replication/expression systems are also vulnerable to xenobiotics attacks due to its own structural feature. Many adverse drug reactions are related to mtDNA injury. The mtDNA-related adverse drug reactions caused by nucleoside reverse transeriptase inhibitors（ NRTIs）, antitumor drugs and antibiotic, as well as the related mechanisms were reviewed in this paper. The prevention and therapeutic methods against mtDNA-related drug adverse reactions were also discussed.
出处
《药学进展》
CAS
2010年第9期392-398,共7页
Progress in Pharmaceutical Sciences
基金
中医药行业科研专项(No.200707008)
十一五科技重大专项(No.2009ZX09302-002)
国家青年自然科学基金(No.30701106)
关键词
线粒体DNA
不良反应
核苷类逆转录酶抑制剂
抗肿瘤药
抗生素
防治
mitochondrial DNA
adverse drug reaction
nucleoside reverse transcriptase inhibitor
antitumor drug
antibiotic
prevention and therapy
