摘要
目的：研究酢浆草对高脂血症大鼠血脂代谢的影响。方法：SD雄性大鼠高脂饮食4周，检测高脂血症形成，然后连续给予辛伐他汀、酢浆草高、中、低剂量4周，检测血清总胆固醇（TC）、甘油三脂（TG）、高密度脂蛋白一胆固醇（HDL—C）、低密度脂蛋白一胆固醇（LDL—C）、丙氨酸氨基转移酶（ALT）、门冬氨酸转氨酶（AST）的含量，测定肝指数，并同时进行肝脏的病理学检查。结果：酢浆草剂量组血清总胆固醇（TC）、低密度脂蛋白一胆固醇（LDL—C）、丙氨酸氨基转移酶（ALT）、肝指数较对照组降低，高密度脂蛋白（HDL—c）升高，肝脏组织学病变减轻，并呈现出一定的量效关系÷结论：酢浆草可调解高脂大鼠的血脂水平，并对肝脏具有一定的保护功能。
Objective To study the effect of Sorrel on blood-lipid of experimental hyperlipemia in rats. Methods male SD rats were given fat rich diet for 4weeks, check the degree of hyperlipoidemia and hepatosomatic index, then the rats were given Simvastatin, high, middle, and low dose of wood sorrel for 4 weeks. The total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） and ALT , AST in serum were measured, check Liversomatic index （LSI） . Liver samples were observed pathologically. Results the level of TC, LDL-C, ALT and LSI of Sorrel Treatment group decreased compared with control group, and the HDL-C rised. its action was of dose-dependent. Conclusion The Sorrel coud reduce the level of Blood Lipid in Obese Rats Induced by Abundant Fat Food, and has protective function for live.
关键词
酢浆草
高脂血症
肝指数
wood sorrel
hyperlipidemia
hepatosomatic index
