摘要
目的:探讨VEGFR-3在早期宫颈癌进展过程中的作用。方法:免疫组织化学法检测41例早期子宫颈癌(ⅠA～ⅡA)组织中VEGF-C、VEGF-D、VEGFR-3的表达,同时检测VEGFR-3标记的脉管密度(MVD),分析其与临床病理因素的关系。结果:(1)VEGFR-3除于淋巴管内皮细胞表达外,部分血管内皮细胞也有表达。形态学上VEGFR-3阳性脉管部分为血管,部分为淋巴管,主要分布于肿瘤组织周围间质中。肿瘤细胞中可见VEGF-C、VEGF-D、VEGFR-3蛋白表达,其表达阳性率分别为48.7%(20/41)、58.5%(24/41)、63.4%(26/41);(2)肿瘤细胞中VEGFR-3蛋白表达与宫颈癌患者月经状态、组织学分级、组织学类型无关,与临床分期、淋巴结转移、淋巴管浸润及VEGF-C、D蛋白表达相关;MVD与月经状态、组织学分级、组织学类型、淋巴结转移、淋巴管浸润均无关,与临床分期及VEGF-C、D蛋白表达相关。结论:VEGFR-3可能通过促进肿瘤血管生成和淋巴管生成,参与了早期宫颈癌的恶性进展。
Objective：To investigate the role of vascular endothelial growth factor receptor（VEGFR）-3 in the early stages of cervical cancer.Methods：The expression of VEGFR-3,vascular endothelial growth factor（VEGF）-C,and VEGF-D in the early stages（ⅠA～ⅡA） of cervical cancer in 41 patients were detected by immunohistochemical analysis,the VEGFR-3-marked vascular density（MVD） was also examined and the relationship between these factors and clinical/pathological features was analyzed.Results：VEGFR-3 was found to be expressed in lymphatic endothelial cells and,to a certain extent,in vascular endothelial cells.The VEGFR-3-positive vessels were mostly distributed in the stroma surrounding the tumor tissues,and these vessels were morphologically divided in blood vessels and lymphatic vessels,respectively.Cancer cells were found to express VEGF-C,VEGF-D,and VEGFR-3,and their positive expression rate was 48.7%（20/41）,58.5%（24/41）,and 63.4%（26/41）,respectively.The VEGFR-3 expression in the cancer cells of cervical cancer patients was found to be correlated with the clinical stage,lymph node metastasis,lymphatic invasion,and expressions of VEGF-C and VEGF-D,but unrelated to the menstrual status,histological grading,and histological classification.MVD was correlated with the clinical stage,expressions of VEGF-C and VEGF-D,and unrelated to the menstrual status,histological grading,histological classification,lymph node metastasis,and lymphatic invasion.Conclusion：VEGFR-3 may play an important role in malignant progression of early stages of cervical cancer by promoting angiogenesis and lymphangiogenesis.
出处
《现代妇产科进展》
CSCD
北大核心
2010年第8期569-572,共4页
Progress in Obstetrics and Gynecology
