摘要
目的:为评价改水降氟对地方性氟中毒的防治效果。方法:检测分析了(未改水)病区组、改水病区组、非病区组8～12岁儿童的尿氟和氟毒性效应指标。结果:尿氟均值病区组明显高于改水病区组(P<0.01)和非病区组(P<0.01);尿羟脯氨酸(HOP)排泄量均值病区组亦明显高于改水病区组(P<0.01)和非病区组(P<0.01)改水病区组8～12岁儿童氟斑牙患病率由10年前的82.4％降至6.45％,明显低于病区组(P<0.01)。斑釉齿指数呈依次递减趋势,病区组、改水病区组、非病区组分别为0.73、0.03、0.026。血清肌酸磷酸激酶(CPK)活性均值病区组非常明显地高于改水病区组(P<0.01)和非病区组(P<0.01)。上述各指标改水病区组与非病区组比较,均无显著性差异(P>0.05)。结论:改水降氟后,人群氟暴露水平下降,致使体内氟负荷减轻,氟毒性效应指标改善,起到了明显的防护作用。
To assess the effects of defluoride of drinking water. Methods:The urine fluorine and indices of fluoride toxic offecting were determined for three groups of children which were 8 - 12 year old. The three groups were nondefluoride group,defluoride group and non - epidemic area group. Results: The means of urine fluorine of non - defluoride group was much higher then that of defluoride (P < 0.01) and non - epidemic area group( P < 0.01) . The mean of urine hydroxyproline ( HOP) was much higher than that of defluoride group( P < 0.01) and non - epidemic area group ( P < 0.01). After ten years of defluoride of drinking water,the rate of dental fluorosis dropped from 82.4%to 6.45% .The rate 6.45% was much lower than that of non - defluoride group ( P < 0.01) . The dental fluorosis indices of non - defluoride group, defluoride group and non-epidemic area group were decrasing progressively,namely 0.73,0.03.,0.026. In the non-defluoride group the mean of activity of urine creatine phosphokinase(CPK) was much higher than that in defluoride group ( P < 0.01) and non - epidemic area group (P<0.01) .Between the defluoride group and non- epidemic area group,the indices mentioned above were no significantly defference ( P > 0.05) . Conclusion; After defluoride of drinking watwr, the body fluoride load come down and indices of fluoride toxic effecting be improved,because of the decresing of levels of exposure to fluorine.
出处
《中国地方病防治》
1999年第2期60-68,共9页
Chinese Journal of Control of Endemic Diseases
关键词
氟中毒
防治
改水降氟
氟负荷
儿童
氟斑牙
Defluoride of drinking water
Urine fluorine
Hydroxyproline
Dental fluorsis
Creating phosphokinase
