摘要
目的：探讨检测胆碱酯酶活性对决定抢救有机磷农药中毒患者阿托品用量的指导作用。方法：将７９例口服有机磷农药中毒患者随机分为２组，观察组５１例，对照组２８例；观察组根据胆碱酯酶活性测定结果，不同中毒程度使用不同量的阿托品，对照组则根据１９７４年卫生部规定标准分中毒程度决定使用阿托品量。结果：观察组平均阿托品用量（３００．５±２０４．６）ｍｇ，治愈４９例，治愈率９６．１％，无一例因阿托品过量或病情反跳死亡。对照组平均阿托品用量（４８０．２±２２０．１）ｍｇ，治愈２３例，治愈率８２．１％；死亡５例中有３例因阿托品中毒致死，１例因病情反跳而死亡。结论：监测胆碱酯酶活性决定使用阿托品用量方法可减少阿托品用量，避免阿托品过量中毒，还能及时预测病情反跳，防止过早减量或停药造成严重后果。
Objective:To assess the clinical significance of monitoring cholinesterase as a guideline of atropine dosage during emergency treatment of patients with organophosphorus pesticide poisoning.Methods:79 patients with organophosphorus pesticide poisoning were randomly divided into two groups.There were 51 cases in the study group,28 cases served as the controls.In the study group,various doses of atropine were used according to cholinesterase determination in patients with different degree of acute poisoning.Results:In the study group,the mean dose of atropine was (300 5±204 6)mg per case and cure rate was 96 1%,and no one died of atropine poisoning or recurrence of symptoms.In the controls,however,the mean dose of atropine was (480 2±220 1)mg per case and cure rate was 82 1%.Of 5 cases with fatal outcome,1 and 3 cases died of recurrence of symptoms and atropine poisoning,respectively.Conclusions:By monitoring cholinesterase one can markedly reduce atropine dosage to avoid atropine poisoning or recurrence of symptoms in the emergency treatment of organophosphorus pesticide poisoning,thereby preventing complications due to untimely withdrawal of atropine.
出处
《中国危重病急救医学》
CAS
CSCD
1999年第5期292-293,共2页
Chinese Critical Care Medicine
关键词
有机磷农药中毒
胆碱酯酶
阿托品
治疗
organophosphorus pesticide poisoning cholinesterase atropine
