摘要
目的探讨硝苯地平联合特拉唑嗪治疗老年原发性高血压临床疗效及安全性。方法选取2008—2009年我院初诊为原发性高血压的老年患者,应用硝苯地平和特拉唑嗪联合治疗,疗程12周,测定患者治疗前后血压、血脂、血糖水平,合并良性前列腺增生患者评定治疗前后国际前列腺症状(IPSS)评分及生活质量(QOL)评分,并记录患者不良反应。结果治疗后有效35例,显效14例,无效4例,总有效率为92.5%。治疗后老年原发性高血压患者收缩压、舒张压、三酰甘油、总胆固醇、高密度脂蛋白及空腹血糖水平均较治疗前明显降低,差异有统计学意义(P<0.05)。21例合并良性前列腺增生老年男性原发性高血压患者治疗后IPSS评分和QOL评分较治疗前明显降低,差异均有统计学意义(P<0.05)。患者均未出现严重不良反应。结论硝苯地平联合特拉唑嗪治疗老年原发性高血压安全有效,血压降低显著,且具有很好的降血脂、血糖作用,能提高合并良性前列腺增生老年男性的生活质量,值得广泛推广使用。
Objective To evaluate the therapeutic effect of Nifedipine and Terazosin on elderly hypertension and its safety.Methods Elderly patients,diagnosed as primary hypertension in our hospital from the year of 2008 to 2009,were treated with Nifedipine and Terazosin,12 weeks.Before and after treatment,the levels of blood pressure,lipid,glucose were determined,adverse reactions recorded and the scores of International Prostate Symptom（IPSS） and quality of life（QOL） performed if patients complicated by benign prostatic hyperplasia（BPH）.Results After treatment,35 patients had effect,14 had obvious effect,4 had no,the total effective rate was 92.5%.Systolic or diastolic blood pressure,levels of triglyceride,total cholesterol,high density lipoprotein and fasting blood glucose were lower after treatment than before（P0.05）,and the IPSS and QOL scores significantly lower after treatment than before in 21 primary hypertension patients complicated by BPH（P0.05）.Conclusion Combination of Nifedipine and Terazosin,safe and with good effects of lowering blood pressure,lipid and glucose,improving elderly patients′ QOL,is worthy of widely spreading.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第24期2723-2725,共3页
Chinese General Practice
