摘要
术后认知功能障碍(POCD)是一种严重的术后并发症,在老年人中发病率较高,多数为一过性的,少数严重者可影响术后生活质量。普遍认为POCD的诱发与年龄、麻醉方法、药物、手术因素、基础疾病等有关。其发病机制至今尚未明确,可能与载脂蛋白E基因、中枢炎症、乙酰胆碱有关。诊断至今尚无统一标准,也无确切的实验室指标,但近期实验证实载脂蛋白E基因对于老年人POCD有预警意义。
Postoperative cognitive dysfunction（POCD）is one of the severe postoperative complications.It occurs more frequently in elder patients,the majority of which is transient but can influence the postoperative quality of life in the minority of severe POCD cases.It is known that POCD is associated with age,anesthesia,medicine,operative factors,and concurrent diseases.The pathogenesis of POCD is unclear until now,possibly associated with apolipoprotein E（ApoE）genotype,central inflammation and acetylcholine（Ach）.Up to now the diagnosis still has no unified standard or accurate laboratory measure.However,in recent days,some studies confirm ApoE gene helpful to predict POCD in elder patients.
出处
《医学综述》
2010年第18期2780-2782,共3页
Medical Recapitulate
