摘要
蛋白质-营养不良是肝硬化病人最常见的并发症之一。肝脏作为蛋白质、脂类和糖代谢的主要器官,病变后的代谢紊乱随之而来。不适宜的蛋白质-能量摄入只会加重病情最后发生肝性脑病等危及生命的严重后果。因此,肝硬化病人的营养管理显得尤为重要,氨基酸的适宜供给无疑是营养治疗的重中之重。已知支链氨基酸能通过刺激肝细胞合成、减少肝损伤后的分解代谢等诸多方式改善营养状况,但是各种试验结果仍存在争议。最佳适宜量究竟多大,安全性范围的设定以及确切的保护机理等问题仍待进一步深入研究。
Protein-calorie malnutrition may be observed in liver cirrhosis and it adversely affects patient outcome.As liver plays a major role in metabolism,nutritional management in these patients must be received high priority.The most important metabolic impairment in patients with cirrhosis is the change in amino acids metabolism.Adequate administration of amino acids could improve their nutritional status and result in a better quality of life,so it is imperative.The mechanism for the beneficial effects of branched-chain amino acids（BCAAs） might be stimulating hepatic protein synthesis,favoring liver regeneration and reducing postinjury catabolism.However,there is no consensus on which is the best diagnostic criteria for caloric-protein malnourishment（CPM） in cirrhosis,the exact mechanism of action is still not clear and the basis for arriving at a consensus regarding the optimal dose of BCAAs supplementation still need further research.
出处
《氨基酸和生物资源》
CAS
2010年第3期63-67,75,共6页
Amino Acids & Biotic Resources
关键词
肝硬化
支链氨基酸
营养不良
营养支持
hepatocirrhosis
branched-chain amino acids
malnutrition
nutritional support
