摘要
以联苯四胺、芳香醛为原料,DMF为溶剂,KI为催化剂,在空气存在下回流反应,合成了6种新的联苯并咪唑化合物,产率较高(58.4%～98.0%),其结构用IR、1HNMR、13CNMR、MS、元素分析等测试技术进行了表征。适宜的合成条件是:反应温度150℃,反应时间12h。初步测试表明,目标化合物对培养人肝癌Bel-7402细胞生长有一定抑制活性。
Using DMF as solvent,3,3＇-diaminobenzidine and aromatic aldehydes as starting materials,and KI as catalyst,six new bisbenzimidazoles were synthesized in the presence of air.The structures of the compounds were characterized by means of FTIR,1↑H NMR,13↑C NMR,MS and elemental analysis.The optimal synthetic conditions were investigated.When the temperature was 150 ℃ and the reaction time was 12 h,the six compounds were obtained with yields in the range of 58.4% to 98.0% .The new method with readily available catalyst is advantageous to conventional synthetic process of bisbenzimidazoles due to its less steps,simpler operations,easier post-processings and higher yields.The anti-tumor activities of the target compounds were preliminarily examined via MTT method on Bel-7402 cell in vitro,and they exhibited certain inhibition activities.
出处
《应用化学》
CAS
CSCD
北大核心
2010年第9期1017-1020,共4页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金(20772035)
广东省自然科学基金(5300082)
广东药学院中青年骨干教师培养基金
广东省科技计划项目(2007B031513004)资助项目
关键词
联苯并咪唑
合成
表征
抗癌活性
bisbenzimidazoles
synthesis
characterization
anti-cancer activity
