摘要
目的观察2型糖尿病患者在口服降糖药物血糖控制不佳时,应用甘精胰岛素和中性胰岛素的疗效和安全性。方法口服降糖药物血糖控制不佳的2型糖尿病患者43例,随机分为治疗组和对照组。治疗组23例在口服降糖药基础上给予甘精胰岛素治疗,对照组20例在口服降糖药基础上给予中效胰岛素治疗。观察2组疗效。结果治疗3个月后,2组空腹血糖(FBG)、糖化血红蛋白(HbA1c)均较治疗前明显下降(P<0.05),且治疗组的FBG[(6.12±1.11)mmol/L]较对照组的[(7.30±1.21)mmol/L]下降更为显著(P<0.05)。治疗后治疗组HbA1c达到6.5%的比例为30.3%明显高于对照组的22.5%(P<0.05)。治疗后治疗组的血糖变异系数(CV)为35.5±10.5明显低于对照组的42.2±13.7(P<0.05)。治疗组低血糖事件发生率低于对照组(P<0.05)。结论口服降糖药治疗血糖仍控制不佳时,联合甘精胰岛素是安全、有效的启动胰岛素的方案。
Objective To observe the effect and safety of using insulin glargine and intermediate-acting insulins,when patients with type 2 diabetes in poor glycemic control with oral antidiabetic drugs.Methods 43 cases patients were randomly divided into treatment group and control group.Treatment group（23 cases）on the basis of the oral medication were given insulin glargine therapy,control group（20 cases）on the basis of oral insulin were given intermediate-acting insulins.Observed the effect of two groups.Results After 3 months of treatment,compared with before treatment,fasting blood glucose（FBG）,glycosylated hemoglobin（HbA1c）of two groups decreased significantly（P0.05）,and FBG of treatment group[（6.12±1.11）mmol/L] was even more lower than that in control group[（7.30±1.21）mmol/L]（P0.05）.After treatment,the proportion of HbA1c by 6.5% to 30.3% was higher than that in control group（22.5%）（P0.05）.After treatment,blood glucose coefficient of variation（CV）（35.5±10.5）was significantly lower than that in the control group（42.2±13.7）（P0.05）.Low blood sugar event rate of treatment group was lower than control group（P0.05）.Conclusion Association with glargine is an available and safe insulin therapy in patients with type 2 diabetes mellitus poorly controllecd by oral antidiabetes drugs.
出处
《临床合理用药杂志》
2010年第18期32-33,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
甘精胰岛素
中效胰岛素
口服降糖药
Glargine
Intermediate-acting insulins
Oral antidiabetes drugs
