摘要
目的了解川崎病（KD）的发病情况、分布和临床特点,提高对KD的诊断水平及治疗效果。方法按日本KD研究中心提供的KD诊断标准、问卷表格和调查方法,回顾性对该院KD患儿进行调查,收集2003年1月至2008年12月的KD患儿住院资料,对发病年龄、性别、季节、临床表现、影象学特征、各系统及心血管并发症、治疗及预后进行回顾性分析。结果 6年间共收治KD患者235例,发病有逐年增多趋势,但未发现流行,发病高峰为1~4岁,男女比例为1.64∶1。全年均可发病,但以4~6月为高峰,10~12月发病最低,急性期病死率为0.43%,死因为冠状动脉瘤破裂,冠状动脉异常率为46.8%,再发率为1.7%。本病主要用阿司匹林及大剂量静脉注射丙种球蛋白治疗,一次大剂量应用丙种球蛋白有效率为94.89%。结论 KD的发病男孩多于女孩,春季多见,大剂量应用丙种球蛋白和阿司匹林治疗有效,早期诊断、及时治疗、长期随访对KD预后有重要意义。
Objective To investigate the incidence,distribution and clinical features of Kawasaki disease in our hospital.Methods Retrospectively analyzing the ages,gender,onset seasons,clinical manifestations,imageological features,cardiovascular and other system′s complications,treatment and prognosis of the children with Kawasaki disease admitted in our hospital from January.2003 to December.2008,the questionaires were made according to methods supplied by Japan Kawasaki Disease Investigating Center.Results The total number of Kawasaki disease was 235 cases with increasing tendency of morbidity but no epidemicity.The peak age was 1-4 years,male：female = 1.64：1.The peak onset time was April to June and the lowest onset time was October to December.The mortality rate in the acute stage was 0.43% caused by the coronary aneurysms broken.The recurrence rate was 1.7%.The main treatment medicines were aspirin and intravenous immunoglobulin（IVIG） and the effective power of IVIG was 94.89%.Conclusion The male Kawasaki disease patients are more than the female ones and this disease is more common in spring;the morbidity rate of cardiovascular damage is 46.8%;the treatment of aspirin combined with IVIG is effective;early diagnosis and treating on time and long-term following are significant.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第18期2495-2496,2480,共3页
Chongqing medicine
关键词
川崎病
临床调查
诊断
治疗
冠状动脉病变
Kawasaki disease
clinical survey
diagnosis
treatment
coronary artery damage
