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肝动脉移植hUCMSCs短期对终末期肝硬化肝纤维指标的影响 被引量:2

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摘要 目的探讨肝动脉移植hUCMSCs短期对终末期肝硬化肝纤维指标的影响,了解移植hUCM-SCs在终末期肝硬化中对肝纤维的治疗作用。方法选择终末期肝硬化患者52例,随机分为两组,一组为hUCMSCs干细胞治疗组,另一对照组为常规护肝治疗组。由深圳北科公司提供符合要求的hUCMSCs,经肝动脉进行hUCMSCs移植,检测患者移植前及移植后第8周血清肝纤维化标志物,对照组常规用多烯磷酯酰胆碱及甘草酸二胺等常规药物治疗,检查治疗组,对照组的治疗效果。结果治疗组肝纤维化标志物比对照组有明显改善,治疗组HA(透明质酸)、LN(层粘连蛋白)、PCIII(Ⅲ型前胶原)、IV-C(IV型胶原)四项指标治疗前后对比差异均有统计学意义(P<0.05),而对照组只有HA治疗前后对比差异有统计学意义(P<0.05)。结论 hUCMSCs移植治疗终末肝硬化有明显改善肝纤维化的作用。
出处 《海南医学》 CAS 2010年第17期26-27,36,共3页 Hainan Medical Journal
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二级参考文献39

共引文献14041

同被引文献28

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