摘要
目的：探讨葛根素对心肌梗塞犬冠脉侧枝循环的影响及其机制。方法：１２只犬随机分成葛根素处理组（Ｇ组）和对照组（Ｃ组），建立心肌梗塞模型，分别给予葛根素和生理盐水，共２１ｄ，冠脉结扎前、后不同时间点行冠脉造影，并测量心肌毛细血管和供血血管面密度。结果：冠脉结扎后２ｈ和２２ｄ时Ｇ组侧枝血管明显多于Ｃ组，Ｇ组缺血区和梗塞区心肌毛细血管和供血血管面密度较Ｃ组明显增加（Ｐ＜０．０５和Ｐ＜０．０１）。结论：葛根素能促进犬急性缺血心肌侧枝循环的开放和形成，对缺血心肌具有保护作用。
Objective:To evaluate the effect and mechanism of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction. Method:Twelve dogs were randomly divided into puerarin (Gegen su, G) group and control(C) group. the acute myocardial infarction model was built in all dogs.Puerarin or saline was administered for 21 days. Coronary angiography was performed before and after ligating coronary artery. The capillaries and distribution vessel density in tissue sections of myocardium were assessed.Result:Angiography on hour 2 and day 22 after ligating coronary artery revealed significant augmentation of collateral vessels in G group versus controls.Capillaries and distribution vessel density in ischemic and infarctive zone on day 22 revealed statistically significant augmentation in G group versus controls (P<0.05 and P<0.01). Conclusion:Puerarin might improve the opening and forming of coronary collateral circulation to ischemic myocardium in dogs and protect ischemic myocardium.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1999年第5期304-306,共3页
China Journal of Chinese Materia Medica
基金
湖北省科委资助
