摘要
目的探讨洛伐他汀对急性心肌梗死(AMI)患者血清脂联素浓度的影响。方法临床选取AMI患者56例,随机分为常规治疗组(26例)和洛伐他汀组(30例)。两组患者均给予常规药物治疗2周;洛伐他汀组在常规治疗的基础上加用洛伐他汀20mg,每日1次口服,治疗2周。分别于治疗前和治疗后测定血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和脂联素,并进行对比。结果①常规治疗组患者治疗前后对比的血清TG、TC及LDL-C无明显变化,而脂联素浓度明显升高(P<0.05);②洛伐他汀组患者治疗后的血清TG、TC、LDL-C均较治疗前下降,而脂联素浓度明显升高,且治疗后脂联素的升高较常规治疗组更为明显(P<0.05)。结论洛伐他汀能改善AMI患者的血脂水平,显著升高血清脂联素浓度。
【Objective】 To study the effect of lovastatin on serum concentration of adiponectin in patients with acute myocardial infarction（AMI）.【Methods】56 patients with AMI were divided into conventional treatment group（n =26） and lovastatin group（n =30）.Patients in both groups were given conventional treatment for 2 weeks,and patients in the lovastatin group were given orally lovastatin（20 mg/day） simultaneously.Triglycerides（TG）,total cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C） and adiponectin were measured and contrasted before and after treatment in all subjects.【Results】①In the conventional treatment group,the serum concentrations of TG,TC and LDL-C had no changes and adiponectin was obviously increased after treatment（P 0.05）;②Compared to those before treatment,all of TG,TC and LDL-C were obviously lower,and adiponectin was apparently higher in the lovastatin group.Moreover,increasing of adiponectin after treatment in the lovastatin group was more apparent compared to those in the conventional treatment group（P 0.05）.【Conclusion】 Lovastatin can improve lipid levels,and apparently increase serum concentrations of adiponectin in patients with AMI.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第16期2523-2525,共3页
China Journal of Modern Medicine
关键词
洛伐他汀
急性心肌梗死
脂联素
lovastatin
acute myocardial infarction
adiponectin
