摘要
目的通过研究慢性B淋巴细胞白血病(chronic B cell lymphocytic leukemia,B—CLL)CD4^+CD25^+highCDl27^Low和CD19^+CD23^+的相关性,探讨CD4^+CD25^+highCDl27^Low在B—CLL发生发展过程中的作用。方法将20例初次发病的B—CLL患者按临床分期的不同分为O-II期组、III-IV期组,设立正常对照组,应用流式细胞仪检测各组的研究对象外周血中CD4^+CD25^+highCDl27^Low、CD19^+、CD19^+CD23^+的表达量,比较各组间的差异。结果B—CLL O-II期组、III-IV期组患者外周血中CD4^+CD25^+highCDl27^Low、CD19^+、CD19^+CD23^+的表达量均明显高于正常对照组;B—CLL患者III-IV期组的CD4^+CD25^+highCDl27^Low、CDl9^+、CDl9^+CD23^+表达量明显高于O-II期组;CD4^+CD25^+highCDl27^Low、CDl9^+CD23^+有明显的正相关性。结论B—CLL患者外周血中CD4^+CD25^+highCD127^Low的表达量增高,与CD19^+、CD19^+CD23^+的表达量增高明显相关,可能是B—CLL患者CD19^+CD23^+克隆性增生原因之一.
Objective To investigate the correlation of CD4^+CD25^+highCDl27^Low with CD19^+CD23^+ in patients with chronic B cell lymphocytic leukemia (B-CLL). Methods Twenty cases of B-CLL were classified as phase O-II group and phase Ill-IV group. CD4^+CD25^+highCDl27^Low, CD19^+, CD19^+CD23^+ were analyzed by flow cytometry. Results CD4^+CD25^+highCDl27^Low, CD19^+ and CD19^+CD23^+ in B-CLL patients were significantly higher than those of normal controls; and the above markers in phase Ill-IV group were significantly higher than those in phase O-II group. There was a positive correlation of CD4^+CD25^+highCDl27^Low with CD19^+ and CD19^+CD23^+. Conclusion CD4^+CD25^+highCDl27^Low is highly expressed in B-CLL and is positively correlated with CD19^+ and CD19^+/CD23^+,which may be a main cause of CD19^+CD23^+-cloning hyperplasia in B-CLL .
出处
《浙江医学》
CAS
2010年第8期1193-1195,共3页
Zhejiang Medical Journal
基金
浙江省医药卫生科学研究基金项目计划(编号:2010KYA015)