摘要
目的探寻通心络胶囊对2型糖尿病合并动脉粥样硬化病变的作用机理。方法将SD大鼠制备糖尿病合并动脉粥样硬化模型,随机分为空白组、模型组、对照组(贝那普利)和治疗组(通心络胶囊)。分别予相应药物灌胃8周后取材,放免法检测血清内皮素(ET)和血管紧张素Ⅱ(AngⅡ)含量。结果治疗组大鼠的血清ET、AngⅡ水平较模型组降低,差异有统计学意义;同对照组相近。结论通心络胶囊具有改善糖尿病合并动脉粥样硬化病变内皮功能的作用,其机制可能与降低ET、AngⅡ水平有关。
Objective：To study the mechanisms of Tongxinluo Capsule on diabetic atherosclerosis.Methods：These male SD rat models were divided randomly into the normal group,the model group,the control group （with benazepril）,the treatment group （with Tongxinluo Capsule）. With corresponding drug intragastric administration in each group for 8 weeks,the ET content and the AngⅡ level were detected by the radioimmunological method. Results：The ET and the AngⅡin the treatment group were lower than those in the model group. These levels were similar to those in the control group. Conclusion：The mechanism that the endothelial function of the diabetic atherosclerosis could be improved by the Tongxinluo Capsule might be related to the reduction the ET level and the AngⅡcontent.
出处
《中国中医急症》
2010年第9期1553-1553,1569,共2页
Journal of Emergency in Traditional Chinese Medicine
