摘要
目的探讨不同浓度空腹血糖的雄性自发性糖尿病Goto-Kakizaki（GK）大鼠行胃远端大部切除及胃空肠Roux-en-Y吻合术对血糖的影响。方法 GK大鼠根据术前空腹血糖浓度分为4组（每组8只）：A组（血糖〈10 mmol/L）,B组（10~15 mmol/L）,C组（15~20 mmol/L）,D组（〉20 mmol/L）,均行胃空肠Roux-en-Y吻合术。检测各组术前及术后1,3,6,12,24周空腹血糖水平和空腹血清胰岛素,计算血糖下降率和监测胰岛素的变化。结果各组大鼠24周血糖下降率为：A组32.6%,B组44.3%,C组40.3%,D组30.0%。各组术后血清胰岛素水平与术前比较差异均无统计学意义（P〉0.05）。结论仅就血糖控制效果而言,胃远端大部切除及胃空肠Roux-en-Y吻合术对各组大鼠空腹血糖出现不均一的控制效果,而以术前空腹血糖水平介于10~20 mmol/L的效果较为明显。
Objective To evaluate the effect of gastric bypass on fasting blood glucose levels in Goto-Kakizaki（GK） rats.Methods Thirty-two GK type 2 diabetic rats were devided into four groups with different fasting blood glucose level： Group A,（10 mmol/L）;Group B,（10~15 mmol/L）;Group C,（15~20 mmol/L）;Group D,（20 mmol/L）.Rats were observed for 24 weeks after gastric bypass（GBP） surgery.Fasting blood glucose level and fasting insulin level were measured at 0,1,3,6,12 and 24 wks postoperatively.The 24-week descend ratio of glucose after operation was calculated by formula.Results The glucose descend ratio of each groups was 35.4%,44.3%,40.3% and 30.1%,respectively.But,campared to pre-operation,the insulin level of all groups showed no significant change（P0.05）.Conclusions In spontaneous type 2 diabetes mellitus rats,gastric bypass operation was effective in all the groups in terms of glucose control.But the effect on glucose control varied among the groups.These findings suggest that there is more marked effect when the preoperative fasting blood glucose level between 10 mmol/L and 20 mmol/L.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2010年第9期993-996,共4页
China Journal of General Surgery
关键词
胃转流术
糖尿病/外科学
血糖
胰岛素
大鼠
Gastric Bypass
Diabetes Mellitus/ther
Blood Glucose
Insulin
Rats
