摘要
目的 了解西藏大骨节病病区病情发展趋势,为大骨节病病因研究和防治提供科学依据.方法 设计大骨节病调查表,于2007年7-11月,在西藏拉萨市的林周县、墨竹工卡县和山南地区桑日县的大骨节病病区,对自愿接受调查且有二代以上的家庭进行面对面的询问,并将询问结果填入调查表中;对被调查家庭中的5～14岁儿童,拍摄右手腕X线片.大骨节病诊断参照〈大骨节病诊断标准〉（GB 16003-1995）进行.结果 共收集144个家庭,对905人进行了面谈及临床检查,检出大骨节病患者208人,总检出率为22.98%（208/905）.其中Ⅰ度病人148人,占患病总人数的71.15%（148/208）;Ⅱ度病人43人,占患病总人数的20.67%（43/208）;Ⅲ度病人17人,占患病总人数的8.17%（17/208）.拉萨市和山南地区大骨节病检出率分别为29.73%（102/343）和18.86%（106/562）,两地比较差异有统计学意义（x2=15.257,P＜0.01）.本次共调查男368人,女537人,男性检山率为19.29%（71/368）,女性检出率为25.51%（137/537）,男女检出率比较差异有统计学意义（x2=5.372,P＜0.01）.大骨节病病人主要集中在31～70岁,Ⅱ、Ⅲ度病人主要见于＞40年龄段中.≤20岁年龄组中临床检出患者仅5例,5～14岁儿童X线检出患者10例,检出率为6.85%（10/146）.结论 拉萨市和山南地区所属的大骨节病病区病情比较稳定,并呈现下降趋势.但是在儿童中仍有X线诊断阳性病例,应引起有关部门的注意,进一步强化防制措施的落实.
Objective To assess the endemic trend of Kaschin-Beck disease in Tibet and to provide scientific basis for prevention and etiology study of the disease. Methods A questionnaire designed by us was administered to 905 participants who were from Lhundrop county, Medro Gongkar county of Lhasa municipality and Sangri county of Lhoka region in July to November, 2007. The Kashin-Beck disease diagnostic criteria（GB 16003-1995） was used for clinical diagnosis, and children 5 to 14 years old were taken right wrist X-ray film for diagnosis.Results One hundred and forty-four genealogies were recruited in this study. The interview and clinical examination were done to 905 persons, 208 persons were detected with Kaschin-Beck disease, and the detectable rate was 22.98%（208/905）. The numbers of patients with degrees Ⅰ , Ⅱ and Ⅲ of Kaschin-Beck disease were 148, 43 and 17, respectively, with proportion of 71.15%（148/208）, 20.67%（43/208） and 8.17%（17/208） out of all patients, respectively. The detectable rates of Kaschin-Beck disease were 29.73% （102/343） and 18.86%（106/562）, respectively in Lhasa and Lhoka district, and the difference between this two districts was statistically significant（x2= 15.257, P〈 0.01） . A total of 368 males and 537 females were recruited in this study, the detectable rates of male and female with Kaschin-Beck disease were 19.29% （71/368） and 25.51% （137/537）, respectively,and the difference between male and female was statistically significant （x2 = 5.372, P 〈 0.01） . In this study most patient were between 31 to 70 years old, the patients with degrees Ⅱ or Ⅲ of Kaschin-Beck disease were mostly above 40 years old. There were only 5 patients who were less and equal 20 years old in chinical diagnosis. The Xray positive detectable rate of children between 5 to 14 years old was 6.85% （10/146）. Conclusions The condition of Kashin-Beck disease area is relatively stable in these two regions in recent years, and shows a downward trend. However, there are still positive child cases diagnosed by X-ray, which should arouse the attention of the relevant departments to further strengthen the implementation of control measures.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2010年第5期519-521,共3页
Chinese Jouranl of Endemiology
基金
国家自然科学基金（30660165）
关键词
大骨节病
流行病学研究
数据收集
Kaschin-Beck disease
Epidemiologic studies
Date collection
