摘要
为了提高对疏水性药物的负载量和缓释作用,将海藻酸钠与辛胺进行不同程度的疏水改性。对改性后的聚合物结构进行FTIR、1H NMR表征;并将聚合物分散于3%的CaCl2溶液中制备成凝胶微球,对小分子疏水性药物布洛芬进行了包埋释放实验。结果表明,辛胺侧链成功接枝于海藻酸钠的羧基上,接枝率与辛胺用量成正比,由其制备的凝胶微球对布洛芬包封率提高,且具有较好的药物缓释作用。
In order to increase the loading dose of hydrophobic drugs on alginate and control the drug release rate, sodium alginate was hydrophobically modified with n-octylamine through the reaction of carbodiimide. The modified alginate was characterized with FTIR and 1H NMR. The modified alginate was made into microsphere beads in aqueous solution of 3wt% calcium chloride. A hydrophobic drug of ibuprofen was loaded on the modified alginate for the in vitro investigation on the drug-controlled release. The results indicated that the drug-loaded dose was obviously increased and the release rate could be well controlled.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2010年第9期1568-1570,1574,共4页
Journal of Functional Materials
基金
973国际合作资助项目(中荷战略联盟项目)(2004CB720604)
关键词
海藻酸钠
辛胺
疏水改性
缓释
alginate
n-octylamine
hydrophobical
controlled-release
