摘要
水通道蛋白（aquaporim，AQP）是一组具有高度选择性的水通道蛋白家族。AQP4在脑内星形胶质细胞中含量最高，是中枢神经系统中最主要的水通道蛋白，参与了脑血管病、脑挫伤、肿瘤、炎症等引起的脑水肿的一系列病理学过程。AQP4在脑缺血后水肿形成中的作用机制仍存在争议。选择性调节AQP4的表达，干预其作用环节，将为临床脑缺血后水肿的治疗提供新的思路和手段。
The aquaporins （AQPs） are a group of highly selective water channel protein family, The content of AQP4 in the astrocytes of the brain is the highest. It is the most vital protein in central nerve system. It participates in a series of pathologic processes of cerebrovascular disorders, brain contusion, tumor, and inflammation caused cerebral edema. However, the mechanism of AQP4 in the process of cerebral edema formation remains controversial. Selective modulation of the expression of AQP4 and inter^ntion in part of its role may provide novel ideas and means for the treatment of edema after cerebral ischemia in clinical practice.
出处
《国际脑血管病杂志》
北大核心
2010年第8期624-631,共8页
International Journal of Cerebrovascular Diseases
关键词
水通道蛋白4
脑水肿
血脑屏障
脑缺血
Aquaporin 4
Brain edema
Blood-brain barrier
Brain ischemia
