摘要
目的探讨疤痕子宫妊娠引产方法的安全性和有效性。方法 46例疤痕子宫妊娠引产者按序贯实验分为A组29例和B组17例。A组仅给予经腹羊膜腔内注射利凡诺100 mg,B组经腹羊膜腔内注射利凡诺100 mg同时空腹给米非司酮50 mg,每12小时1次,连服3次。结果 46例均在用药后72 h分娩,无子宫破裂。A组注药后引产时间、宫缩开始到引产结束时间比B组明显缩短(均P<0.01)。A组宫颈成熟为26%,B组宫颈成熟为97%,2组比较差异有统计学意义(P<0.01)。2组产后出血量均<500 mL,2组产后出血量比较差异无统计学意义[(121.0±3.2)mL vs(120.0±2.8)mL,P>0.05]。结论单纯经腹羊膜腔内注射利凡诺100 mg和同时联用米非司酮均安全有效,但利凡诺联合米非司酮用于疤痕子宫妊娠引产,比利凡诺单独使用,产程明显缩短,孕妇无剧烈疼痛,易被患者接受。
Objective To evaluate the safety and efficacy of a potential medical abortion method during mid-trimester in women with a prior caesarean section.Methods Forty-six normal pregnant women with a prior caesarean section were assigned to group A（n=29）and group B（n=17） by sequential experimental design.Women in group A received transabdominal amniotic injection of 100 mg ethacridine lactate,while women in group B received either 100 mg ethacridine lactate injection or 50 mg mifepristone administration during fasting.Drugs were given 3 times（once every 12 hours）.Results Parturition occurred after 72 hours in all women,without scar rupture.Induction time and induction of labor contractions start to the end of time,in group A was significantly shorter than in group B（P0.01）.Cervical ripening rate in group A（26%） was significantly lower than that in group B（97%）（P0.01）.No significant differences were observed in blood loss between the two groups [（121.0±3.2）mL vs（120.0±2.8）mL,P0.05].ConclusionTransabdominal amniotic injection of ethacridine alone or in combination with mifepristone administration is safe and effective for abortion in women with a prior caesarean section.However,combination of ethacridine lactate and mifepristone is more effective and safer,and highly acceptable to pregnant women because of its painlessness and short duration of labor.
出处
《南昌大学学报（医学版）》
CAS
2010年第7期72-74,77,共4页
Journal of Nanchang University：Medical Sciences
关键词
疤痕子宫
妊娠
引产方法
利凡诺
米非司酮
cesarean scar
pregnancy
abortion methods
ethacridine lactate
mifepristone
