摘要
目的观察乌司他丁治疗重症肺炎的临床疗效。方法 120例重症肺炎患者随机分为治疗组和对照组。对照组62例常规治疗;治疗组58例,在常规治疗基础上加用乌司他丁20万U,2次/d。观察患者病情改善情况,监测患者心率(HR)、呼吸频率(RR)、体温(T)、白细胞计数(WBC)、降钙素原(PCT)及氧合指数(PaO2/FiO2)。结果治疗组:显效46例(79%),显效率高于对照组(P<0.05);治疗组HR、RR、T及WBC经治疗后改善情况优于对照组(P<0.05、P<0.01);治疗后3 d,治疗组PCT、氧合指数(PaO2/FiO2)明显改善(P<0.01);对照组治疗后6 d才有明显改善,但治疗组比对照组改善更明显(P<0.01)。结论乌司他丁能有效改善重症肺炎患者的病情,对重症肺炎的救治具有临床意义。
Objective To observe the effect of ulinastatin on severe pneumonia.Methods One hundred and twenty patients with severe pneumonia were randomly divided into two groups：ulinastatin group（n=58）and routine group（n=62）.Both groups were given routine treatment,while the patients of ulinastatin group were given ulinastatin（200 000 U,micro pump per 12 h,5～7 d）in addition.The improvement condition by monitoring the heart rate（HR）,respiratory rate（RR）,temperature（T）,white blood cell（WBC）,procalcitonin（PCT）and oxygenation index were observed.Results The marked effective rate of ulinastatin group was higher than that of control group（79% vs 51.6%,P0.05）.There were significant differences in HR,RR,T,WBC,PCT and oxygenation index between two groups（P0.05,P0.01）.Conclusion Ulinastatin has good effect on patients with severe pneumonia,it has clinical value in treating severe pneumonia.
出处
《实用药物与临床》
CAS
2010年第5期381-383,共3页
Practical Pharmacy and Clinical Remedies
关键词
乌司他丁
重症肺炎
Ulinastatin
Severe pneumonia
