摘要
目的探讨结直肠癌组织中RhoA蛋白的表达及其临床意义。方法应用免疫组织化学法检测92例结直肠癌患者和30例正常结直肠黏膜RhoA蛋白的表达水平。结果结直肠癌组RhoA蛋白阳性率为70．7％，对照组RhoA蛋白表达阴性（P〈0．05）；高、中、低分化结直肠癌RhoA蛋白阳性率依次为43．5％、74。4％和86．7％，差异有统计学意义（P〈0．05）；Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期结直肠癌患者RhoA蛋白阳性率分别为48．6％、77．3％、83．3％和94．1％，随着临床分期的增加而增高（P〈0．05）；有淋巴结转移组和无淋巴结转移组RhoA蛋白阳性率分别为82％和57．1％（P〈0．05）。结论RhoA蛋白表达水平与结直肠癌的分化、侵袭、转移、恶性程度有关。
Objective To study the expression of RhoA protein in eoloreetal earoinoma. Methods The expression of RhoA protein in 92 eases of eoloreetal eeareinoma and 30 eases of normal rectal tissue was deteeted by SP immunohistochemieal technique. Results RhoA protein were negative in 40 eases of normal eoloreetal tissue. In 92 eases of eoloreetal carcinoma, the positive rate of RhoA protein was 70.7 %. It was significantly higher than that in the normal eoloreetal tissue. The positive rate of RhoA protein in high-differentiated ,moderate-differentiated and lowdifferentiated reetal carcinoma were 43.5% ,74.4% and 86.7%, respectively（ P 〈 0. 05 ）. The positive rates of RhoA in phase Ⅰ ,phase Ⅱ ,phase Ⅲ and phase Ⅳ were 48.6% ,77.3% ,83.3% and 94.1% ,respeefively（P 〈0. 05）. The positive rate of RhoA protein in patients with lymphnode mestastasis and non-lymphnode mestastasis were 82% and 57.1% （ P 〈 0. 05 ）. Conclusion RhoA protein could be related with the differentiation,invasion,metastatsis and prognosis of eoloreetal carcinoma.
出处
《中国基层医药》
CAS
2010年第17期2330-2331,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
癌症
侵袭
转移
Careinoma
Invasion
Metastasis
