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Dkk-1在肿瘤中的研究进展 被引量：3

Recent progress of Dkk-1 in tumors
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摘要 DKK-1是一种分泌型糖蛋白,通过结合细胞表面受体LRP5/6、Kremen1/2在Wnt通路中起负调控作用。Dkk-1的表达受p53、MYCN、β-catenin等基因调控。Dkk-1在细胞内的异位表达能抑制多种肿瘤细胞的增殖,但有时能在促凋亡因子存在时诱发凋亡。Dkk-1在一些肿瘤中低表达,而在另一些肿瘤中高表达。Dkk-1在不同肿瘤的发生、发展以及转移这几个阶段中的表达和功能表现出复杂多重的差异。该文就Dkk-1在肿瘤中表达和功能的研究进展作一综述。 DKK-1 is a secretary glycoprotein,which negatively regulates Wnt pathway through binding to surface receptors LRP5/6 and Kremen 1/2. The expression of Dkk-1 is regulated by p53,MYCN,β-catenin,etc. Ectopic expression of Dkk-1 could inhibit cell proliferation,or induce apoptosis with apoptosis enhancing factors. Dkk-1 low-expressed in many tumors,but overexpressed in others. Growing evidences show that Dkk-1 play complex and different roles in tumorigenesis,tumor progression and metastasis of different cancers. We herein review the recent progress in the expression and function of Dkk-1 in tumors.
作者 赵衡 敖军平 李锦军
机构地区 上海交通大学肿瘤研究所癌基因及相关基因国家重点实验室
出处 《生命科学》 CSCD 北大核心 2010年第9期869-872,共4页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(30731160004) 国家重点基础研究发展计划("973"项目)(2009CB521803)
关键词 DKK-1 肿瘤 WNT通路 Dickkopf-1 tumorigenesis Wnt pathway
分类号 Q513.2 [生物学—生物化学] R730.231 [医药卫生—肿瘤]
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参考文献50

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共引文献15

同被引文献38

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生命科学
2010年 第9期

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