摘要
目的：探讨红细胞免疫功能及自然杀伤（ＮＫ）细胞活性在子宫内膜异位症（内异症）发病中的作用，以及两者之间的相关性。方法：采用红细胞Ｃ３ｂ受体花环试验（ＲＣ３ｂＲ）及红细胞免疫复合物花环试验（ＲＩｃＲ）测定４４例内异症患者（内异症组）红细胞免疫功能变化，采用４－甲基偶氮唑盐（ＭＴＴ）法检测患者外周血ＮＫ细胞活性，并与正常妇女（对照组）进行比较。结果：内异症组ＲＣ３ｂＲ及ＮＫ细胞活性低于对照组（Ｐ＜０．０５），其值随内异症病情加重有逐渐下降趋势；内异症组Ⅲ，Ⅳ期患者ＲＩｃＲ较对照组明显升高（Ｐ＜０．０５）。４４例内异症患者ＲＣ３ｂＲ值与ＮＫ细胞活性的降低程度呈直线正相关（ｒ＝０．６６５９，Ｐ＜０．０１）。结论：内异症患者红细胞免疫功能及ＮＫ细胞活性的降低可能与该病的发生与发展有关。
Objective: To study the red cell immune function and natural killer (NK) cell activity in the development of endometriosis. Methods: The red cell immune functions of 44 patients with endometriosis were assayed by means of erythrocyte C3b receptor rosette test and erythrocyte Ic rosette test. The NK cell activities in peripheral blood was assayed by means of MTT assay and compared with that of controls. Results: The RC3bR and NK cell activity of patients with endometriosis were lower than those of controls ( P <0.05), and decreased as the stage of endometriosis increased. The RIcR of patients with stageⅢ,Ⅳendometriosis was higher than that of control ( P <0.05). Positive linear relativity was found between RC3bR and NK cell activity in patients with endometriosis ( r=0.665 9, P <0.01). Conclusion: The defects of red cell immune function and NK cell function may be related to the pathogenesis of the endometriosis.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第3期181-183,共3页
Academic Journal of Second Military Medical University
