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不同孕期铅暴露对大鼠妊娠结局及胎盘MMP-9、TIMP-1表达的影响

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摘要 通过观察Wistar大鼠孕期不同时段铅暴露对妊娠结局及胎盘基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶组织抑制因子-1(TIMP-1)的表达影响,评价孕早期、孕后期及孕全程铅暴露的毒性特点及毒性机制。研究人员将108只Wistar大鼠随机分为4组,每组27只(雌:雄为2:1),用0.025%醋酸铅对各实验组的孕鼠通过自由饮服的方式染毒。
出处 《环境与职业医学》 CAS 北大核心 2010年第9期537-537,共1页 Journal of Environmental and Occupational Medicine
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