摘要
目的验证鼻咽癌的癌基因表达与鼻咽癌生长倾向和放射敏感性的关系。方法检测我院６１例鼻咽癌病人的Ｐ５３、Ｐ２１、ＮＭ２３、ＰＣＮＡ，并分析鼻咽癌病人临床肿瘤生长方式和放射治疗结果。结果鼻咽癌上行性生长者Ｐ５３、Ｐ２１、ＮＭ２３阳性率较高，而ＰＣＮＡ阳性率较低。在Ｐ５３、Ｐ２１、ＮＭ２３三项里鼻咽癌上行性、混合性与下行性三种生长方式间存在明显的梯度变化。Ｐ５３、ＰＣＮＡ在放疗５０Ｇｙ肿物就消退时，阳性率低于肿瘤未消退者，而Ｐ２１、ＮＭ２３变化不大。结论从基因水平证实鼻咽癌生长方式确实存在上、下行两种倾向。另外本文资料还表明Ｐ５３、ＰＣＮＡ与放射敏感性有关，Ｐ２１、ＮＭ２３与放射敏感性关系不明显。
Purpose ToverifytherelationbetweentheexpressionofcancergeneinN.P.C.andgrowingpathandradiosensitivity.MeterialsandMethods:WemeasuredP53,P21,NM23andPCNAfor61patientswithN.P.C.andanalysedclinictumorgrowingstyleandtheresultofradiotherapy.Results:ThepositiverateofP53,P21andNM23washigherandthepositiverateofPCNAwaslowerinN.P.C.withgrowingupstyle.TherewasachanginggraduallyinP21,PCNA andNM23amonggrowingupstyle,mixedstyleandgrowingdownstyle.ThepositiverateofP53andPCNAwaslowerwhentumorwascuredbythe50Gydoseofradiotherapythanthatwhentumorwasntbythe50Gydoseofradiotherapy,thepositiverateofP21,NM23wasnotobviouschange.Conclusion:Itistestifiedatthegenelevelthattherearetwogrowingmethods,growingupandgrowingdowninN.P.C..ThedatashowedthatP53andPCNAisrelatedtotheradiosensitivityandP21 andNM23arentrelatedtotheradiosensitivity.
出处
《福建医药杂志》
CAS
1999年第2期6-7,共2页
Fujian Medical Journal
