摘要
目的评价葆肾康颗粒对大鼠慢性肾衰竭的防治作用。方法除正常组外,其他各组大鼠采用腺嘌呤制备慢性肾衰竭模型。将模型大鼠随机分为模型组,葆肾康颗粒低、中、高剂量组和阳性对照组(给予尿毒清颗粒),观察各组大鼠生化指标及肾脏病理学变化。结果与模型组比较,葆肾康颗粒高剂量组与阳性对照组血尿素氮(BUN)明显降低,血肌酐(Scr)不同程度下降,红细胞(RBC)显著增加;葆肾康颗粒高剂量组血红蛋白(Hb)明显升高;给药组血液钾离子(K+)含量均不同程度降低,肾脏病理损伤均不同程度减轻。结论葆肾康颗粒能有效防治慢性肾衰竭,在降低血肌酐水平和增加血红蛋白含量上具有显著效果,作用与尿毒清颗粒类似。
Objective To evaluate the nephroprotective effects of baoshenkang granules on chronic renal failure（CRF） in rats. Methods Except for the normal control,the rats with CRF induced by adenine were randomly divided into five groups： model,low-,mediate-,high-dosage and positive control group with niaoduqing granules.The biochemical indicators and renal pathology were investigated to find out differences among them. Results Compared with the model group,BUN and Scr were significantly decreased,while RBC was increased in both high-dosage and positive control groups;Hb was elevated only in the high-dosage group.K＋ concentration was lowered in all treated CRF rats.The renal pathological injuries were palliated in CRF rats treated with both baoshenkang and niaoduqing granules. Conclusion Baoshenkang is effective on preventing occurrence of CRF.Furthermore,baoshenkang granules display a similar effect to niaoduqing on Scr reduction and Hb rising.
出处
《医药导报》
CAS
2010年第10期1255-1257,共3页
Herald of Medicine
基金
国家自然科学基金资助项目(基金编号:30700262)
武汉市科学技术计划项目(基金编号:2009520589)
关键词
葆肾康颗粒
尿毒清颗粒
肾衰竭
慢性
防治作用
Baoshenkang granules
Niaoduqing granules
Renal failure
chronic
Nephroprotective effects
