摘要
系统性红斑狼疮(SLE)是一种病因复杂、病变累及全身多个器官和系统的自身免疫病。流行病学调查表明,SLE患者已成为动脉粥样硬化(AS)的高危人群,但原因尚难达成共识。传统危险因素高血压、高血脂等不能完全解释SLE伴随发生的AS,非传统危险因素自身抗体、免疫复合物、炎症等在SLEAS发病中的作用备受关注。脂肪因子参与调节血管活性、免疫、炎性反应等。研究脂肪因子的炎性作用对AS的影响,有助于SLEAS的发现和治疗,提高预后。
SLE is an autoimmune disease with complex causes,which can influence every organ or system all over the body.Epidemiological researches show that patients with SLE have high risks of AS,but the causes remain controversial.Traditional risk factors,such as hypertension and hyperlipemia,cannot fully interpret why AS is always the concomitant condition of SLE.Nontraditional risk factors,such as auto-antibody,immune complex and inflammation have raised great concerns nowadays.Adipocytokines regulate vascular active substance,immunity,and inflammation.Studies on the effects of adipokines inflammation on AS can help the discovery and treatment of AS in SLE and improve the prognosis.
出处
《医学综述》
2010年第19期2915-2917,共3页
Medical Recapitulate
关键词
系统性红斑狼疮
动脉粥样硬化
脂肪因子
炎症
Systemic lupus erythematosus
Atherosclerosis
Adipokines
Inflammation
