摘要
目的探讨睾丸卵黄囊瘤的形态结构特点及免疫组化技术在该瘤的诊断及预后中的意义。方法10例睾丸卵黄囊瘤的存档蜡块，经切片、HE染色，分别以AFP、AAT、HCG、CEA、CK、Vimentin行免疫组化S-D法染色。结果HE染色以疏松网状结构、嗜酸性透明小体、S-D小体、腺体及腺样结构为最常见。免疫组化AAT10例均阳性，阳性范围和强度大于AFP。3例CEA阳性病例中，2例死亡，1例失访。HCG均阴性。Vimentin、CK均阳性。结论免疫组化检测该肿瘤的标记蛋白对诊断和预后的判断有一定价值。AAT可作为此瘤的特征性蛋白标记。CEA与肿瘤的预后可能有一定关系。
Objective To investigate morphological feature and significance of immunohistochemical staining in diagnosis and prognosis of testicular Yolk sac tumor(YST). Methods The HE staining and immunohistochemical analysis of a1-trypsin (AAT),a-fetoprotein (AFP), human chorionic gonadotropin (HCG), carcinoembryonic antigen(CEA), cellular keratin(CK) and vimentin were carried out in 10 cases YST in paraffin-embedded section respectively. Results Loose reticulate structure .eosinophilic clear ball, adenoidal structure , S-D mbody were frequently present in HE staining . AAT was positive in all cases. The positive staining range and intension of AAT were broader and darker than that of AFP. In the 3 cases of CEA positive patients ,2 cases were dead. a case lost following-up. HCG was negative ,while vimentin and CK were positive in all the cases. Conclusions Immunohistochemical staining has reference value in diagnosis and prognosis of testicular YST AAT is good marker of YSTand the expression of CEA might be related to prognosis of the tumor.
出处
《诊断病理学杂志》
CSCD
1999年第2期87-88,共2页
Chinese Journal of Diagnostic Pathology
