摘要
目的探讨不同病理级别胶质瘤组织中VEGF、MMP-7的表达及其临床意义。方法采用二步法免疫组化检测10例正常脑组织和78例胶质瘤组织中VEGF,MMP-7的表达,并与胶质瘤的恶性程度进行相关性分析。结果 VEGF、MMP-7在正常脑组织中表达均为阴性,在不同病理级别胶质瘤中均有表达,并随肿瘤病理级别增高而增高,分别与正常脑组织比较差异均有统计学意义(P<0.01);相关分析发现VEGF表达与MMP-7的表达呈显著正相关(P<0.01)。结论提示VEGF在细胞质内的集聚可促进MMP-7的表达,二者与胶质瘤的发生、发展、侵袭性有关,可反映胶质瘤的恶性程度和病理分级及预后。
Objective To investigate the expression of VEGF and MMP-7 at different levels of glioma and its clinical significance. Methods The expression of VEGF and MMP-7 in 78 cases of glioma and 10 cases of normal brain tissue was detected by using the immunohistochemistry PV-9000 two step method. Results The expression of VEGF and MMP-7 was negative in the normal brain tissue, and higher expression of VEGF and MMP-7 could be observed with the increasing level of glioma. There was a significant difference in the expression of VEGF and MMP-7 between glioma and normal brain tissue. Conclusion The accumulation of VEGF in cytoplasm can promote the MMP-7 expression,and VEGF and MMP-7 might be associated with the occurrence,development and malignance of glioma,showing the malignant degree, patholgical level and prognosis of glioma.
出处
《中国现代医生》
2010年第28期30-31,33,共3页
China Modern Doctor
