摘要
目的 探讨一氧化氮 ( NO)吸入疗法对新生儿持续肺动脉高压 ( PPHN)的疗效、剂量、疗程及安全性。方法 对 1 0例 PPHN患儿进行了吸入 NO治疗 ,浓度以 2 0～ 40 ppm开始 ,6小时后降为 6 ppm持续 36～ 72小时 ,同时在吸入前后动态观测氧合情况、肺动脉压力、血压、心率及高铁血红蛋白 ( MHb)变化。结果 吸入 NO后 30分钟有 7例患儿氧合情况显著改善、肺动脉压力降低 ,对全身血压、心率并无明显影响 ;以 6 ppm维持 36～ 72小时 ,患儿氧合情况持续改善。结论 低浓度、短期吸入 NO能显著改善 PPHN患儿的氧合情况 ,但尚需对吸入NO的剂量、疗程。
To study the effect, dosage and therapy duration of inhaled nitric oxide (iNO) in persistent pulmanory hypertension of the newborn (PPHN).Methods Ten neonates with PPHN were treated with inhaled NO.The beginning concentration of NO was 20～40ppm,and after 6 hours the concentration was decreased to 6ppm which was kept for 36～72 hors. Systemic oxygenation, systemic blood pressure, pulmonary artery pressure, heart rate were monitored during the therapy. Results Systemic oxygenation and pulmonary artery pressure obviously improved in 7/10(70%) cases and sustained improvement in oxygenation occured when the concentration of NO was 6 ppm.There were no significant difference in blood pressure, heart rate and MHb between before and after the therapy. Conclusion Low concentration NO can improve the systemic oxygenation of the newborn with PPHN. The dosage, therapy duration and safety of inhaled NO would be studied deeply.
出处
《新生儿科杂志》
1999年第3期100-103,共4页
The Journal of Neonatology
