摘要
目的:评价丹红注射液治疗不稳定型心绞痛的疗效与安全性。方法:检索并选取国内公开发表的有关丹红注射液治疗不稳定型心绞痛的随机临床对照试验文献,应用Jadad评分法进行质量评价,运用Meta分析进行统计分析。结果:13项研究经Meta分析合并后结果显示,丹红注射液治疗组在减少心绞痛发作次数、改善缺血性心电图和不良反应方面均优于对照组。结论:Meta分析结果显示丹红注射液对不稳定型心绞痛有一定疗效,且不良反应发生率较低,但由于现有研究质量较差,尚需要设计严格、大样本的随机对照试验加以证实。
OBJECTIVE To evaluate the effectiveness and safety of Danhon injection in the treatment of unstable angina pec toris （UAP）. METHODS The literatures both domestic and about random-control clinical trials on Danhon injection for trea ting UAP were retrieved to screen the qualified researches. The Jadad score was used to evaluate the quality. The data was statistically analyzed by Meta analysis. RESULTS 13 studies were incorporated by Meta-analysis and the results showed that Danhon injection group was better than control group in terms of reducing numbers of angina attacks and improving ischemic ECG. CONCLUSION Meta-analysis manifests that Danhon injection has certain curative effect on unstable angina pectoris, and the occurrence rate of adverse effects is lower. Because the quality of present researches is worse, these results await verifi cation with strict design and large-sample randomized control trial.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第19期1671-1674,共4页
Chinese Journal of Hospital Pharmacy
