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转录因子NF-E2相关因子2-抗氧化转录元件信号通路组成与激活机制 被引量：16

The components and activation mechanisms of Nrf2-ARE signal pathway
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作者 钟苑芳 贺凌飞 余日安
机构地区 广东药学院公共卫生学院劳动卫生与环境卫生学系 广东药学院附属第一医院
出处 《中国职业医学》 CAS 北大核心 2010年第5期416-419,共4页 China Occupational Medicine
基金 广东省医学科研基金资助项目(A2008331) 广东省自然科学基金资助项目(9151022401000003) 广东药学院师资队伍建设经费资助
关键词 NRF2 抗氧化元件 Ⅱ相解毒酶
分类号 R363 [医药卫生—病理学]
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参考文献23

  • 1NGUYEN T, NIOI P, PICKETT C B. The Nrt2-antioxidant response element signaling pathway and its activation by oxidative stress [ J ]. J Biol Chem,2009,284(20) :13291 -13295.
  • 2MOI P,CHAN K,ASUNIS I,et al. Isolation of NF-E2-related factor 2 (Nrt2), a NF-E2-1ike basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region[ J ]. Proc Natl Acad Sci, 1994,91 ( 21 ) :9926 - 9930.
  • 3ZHANG D D. Mechanistic studies of the Nrf2-Keapl signaling pathway [J]. Drug Metab Rev,2006,38(4) :769 -789.
  • 4JAIN A K, BLOOM D A, JAISWAL A K. Nuclear import and export signals in control of Nrf2- J-. J Biol Chem,2005,280(32 ) :29158 - 29168.
  • 5NIOI P, NGUYEN T, SHERRATr P J, et al. The earboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation[ J]. Mol Cell Biol,2005,25(24) :10895 - 10906.
  • 6KANG M I, KOBAYASHI A, WAKABAYASHI N, et al. Scaffolding of Keapl to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes [ J ]. Proc Natl Acad Sci USA,2004,101 (7) :2046 -2051.
  • 7RANDLE L E,GOLDRING C E,BENSON C A,et al. Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keapl defence response pathway in CD-I mice [ J ]. Toxicology, 2008,243 (3) : 249 - 260.
  • 8NIOI P,MCMAHOS M,ITOH K,et al. Identification of a novel Nrf2- regulated antioxidant response element (ARE) in the mouse NAD (P) H :quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence[ J]. Bioehem J ,2003,374( Pt 2 ) :337 -348.
  • 9NIOI P,HAYES J D. Contribution of NAD(P) H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocaxbon receptor basic helix-loop-helix transcription factors[J]. Mutat Res, 2004,555 (1/2) :149 - 171.
  • 10FURUKAWA M, XIONG Y. BTB protein keapl targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Rocl ligase [ J]. Mol Cell Biol,2005,25 ( 1 ) : 162 - 171.

二级参考文献14

  • 1Maheshwari RK,Singh AK,Gaddipati J,et al.Multiple biological activities of curcumin:a short review[J].Life Sci,2006,78:2081-2087.
  • 2Iqbal M,Sharma SD,Okazaki Y,et al.Dietary supplementation of curcumin enhances antioxidant and phase Ⅱ metabolizing enzymes in ddY male mice:possible role in protection against chemical carcinogenesis and toxicity[J].Pharmacol Toxicol,2003,92:33-38.
  • 3Sheweita SA,Tilmisany AK.Cancer and phase Ⅱ drugmetabolizing enzymes[J].Curr Drug Metab,2003,4:45-58.
  • 4Chen C,Kong AN.Dietary chemopreventive compounds and ARE/EpRE signaling[J].Free Radic Biol Med,2004,36:1505-1516.
  • 5Lee JS,Surh YJ.Nrf2 as a novel molecular target for chemoprevention[J].Cancer Lett,2005,224:171-184.
  • 6Habig WH,Pabst MJ,Jakoby WB.Glutathione Stransferases.The first enzymatic step in mercapturic acid formation[J].J Biol Chem,1974,249:7130-7139.
  • 7Prochaska HJ,Santamaria AB.Direct measurement of NAD(P)H:quinine reductase from cells cultured in microtiter wells:a screening assay for anticarcinogenic enzyme inducers[J].Anal Biochem,1988,169:328-336.
  • 8Okazaki Y,Iqbal M,Okada S.Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen,ferric nitrilotriacetate[J].Biochim Biophys Acta,2005,1740:357-366.
  • 9Dickinson DA,Iles KE,Zhang H,et al.Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression[J].FASEB J,2003,17:473-475.
  • 10Gao J,Kashfi K,Liu X,et al.NO-donating aspirin induces phase Ⅱ enzymes in vitro and in vivo[J].Carcinogenesis,2006,27:803-810.

共引文献15

同被引文献175

引证文献16

二级引证文献59

中国职业医学
2010年 第5期

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