摘要
过氧化物酶体增殖物激活受体(PPAR)是配体激活的核转录因子,在糖脂代谢中发挥重要作用,这在一定程度上改善糖尿病血脂异常和胰岛素抵抗,减少心血管并发症发生的危险因素。同时,动物模型的数据显示,PPAR的激活也有独立的抗动脉粥样硬化作用,包括抑制血管炎症,氧化应激和激活肾素-血管紧张素系统等。这使PPAR成为研究治疗糖尿病及其心血管并发症理想的靶基因。
Peroxisome proliferators activated receptors（PPAR）are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis.To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance,these agents have been considered to reduce cardiovascular risk.However,data from murine models suggests that PPAR agonists also have independent anti-atherosclerotic actions,including the suppression of vascular inflammation,oxidative stress,and activation of the renin angiotensin system and so on.These observations make PPAR an attractive agent for therapeutic treatments of cardiovascular complications in type 2 diabetes.
出处
《医学综述》
2010年第20期3139-3142,共4页
Medical Recapitulate
