摘要
目的:探讨高脂饮食对SD大鼠主动脉内皮凋亡的影响以及针刺对该影响的作用。方法:17只刚断乳的SD大鼠经高脂喂养12周后检测血清NO和MPO,按体重随机分为模型组(8只)和针刺组(9只),干预4周后检测血清NO、MPO和主动脉NO、SOD、MDA、bax、bcl-2,并设普食对照组(9只)。结果:模型组血清MPO和主动脉MDA、bax均明显高于对照组,血清和主动脉NO、主动脉SOD和bcl-2明显低于对照组;针刺后血清MPO和主动脉MDA、bax明显降低,血清和主动脉NO、主动脉SOD和bcl-2明显增加。结论:高脂饮食增加了SD大鼠主动脉内皮的氧化应激水平,造成主动脉内皮凋亡增加;针刺能够减轻高脂饮食大鼠主动脉内皮的氧化应激,改善主动脉内皮的凋亡。
Objective： To investigate the high-fat diet on SD rat aortic endothelial apoptosis,and the impact of the role of acupuncture.Methods： 17 SD rats were just weaning high fat diet for 12 weeks of serum NO and MPO,were randomly divided into model group（n=8） and the acupuncture group（9 rats）,serum after 4 weeksNO,MPO and aortic NO,SOD,MDA,bax,bcl-2,and let normal diet control group（9 rats）.RESULTS： MPO serum and aortic MDA,bax were significantly higher in serum and aortic NO,aortic SOD and bcl-2 was significantly lower than the control group;acupuncture serum MPO and aortic MDA,bax waslower serum and aortic NO,aortic SOD and bcl-2 significantly increased.Conclusion： The high fat diet increased the SD rat aortic endothelial oxidative stress,resulting in increased apoptosis of aortic endothelial;Acupuncture can reduce the high fat diet rat aortic endothelial oxidative stress and improve the withered aortic endothelialdeath.
出处
《中医药导报》
2010年第10期55-57,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
中国博士后基金资助(20090461491)
