摘要
目的:探讨新疆维吾尔族白细胞介素-13基因单核苷酸多态性与慢性阻塞性肺疾病易感性的关系。方法:140例慢性阻塞性肺疾病稳定期患者和140例健康者,应用PCR、DNA测序法检测白细胞介素-13基因启动子-1055C/T位点基因型分布情况;用ELISA测定血清中白细胞介素-13水平。结果:2组白细胞介素-13基因启动-子1055 C/T位点各基因型频率和等位基因频率的分布差异均有统计学意义(P均<0.01);各基因型携带者血浆白细胞介素-13水平差异有统计学意义(P<0.05)。结论:白细胞介素-13基因启动子-1055C/T位点的单核苷酸多态性与新疆和田地区维吾尔族人群的慢性阻塞性肺疾病易感性存在相关性。
Objective To study the association between polymorphism of interleukin-13 and susceptibility to chronic obstructive pulmonary disease in Uygur nationality in Xinjiang.Methods A total of 140 patients with chronic obstructive pulmonary disease（COPD group） and 140 healthy controls（control group） were detected the-1055 locus polymorphism of interleukin-13 with polymerase chain reaction and sequence analysis techniques,and the total plasma interleukin-13 levels were determined with ELISA.Results There were significant differences in the frequency of genotype and allele as well as total plasma interleukin-13 levels between the COPD group and control group（P0.01,P0.05）.Conclusion The genetic polymorphism in-1055 locus of interleukin-13 is correlated to the susceptibility to chronic obstructive pulmonary disease in Uygur nationality in Xinjiang.
出处
《中华实用诊断与治疗杂志》
2010年第10期984-986,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金资助项目(30860235)
关键词
慢性阻塞性肺疾病
白细胞介素13
基因多态性
Chronic obstructive pulmonary disease
interleukin-13
genetic polymorphism
