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3,4-二甲氧基苯乙酸的合成新工艺 被引量：3

An Alternative Process for Preparation of 3,4-Dimethoxyphenylacetic Acid
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摘要 3,4-二甲氧基苯乙酸（1）又名高藜芦酸,可用于合成β受体阻滞药贝凡洛尔（bevantolol）和抗心律失常药维拉帕米（verapamil）等,也是合成异喹啉类生物碱的关键中间体。 3,4-Dimethoxyphenylacetic acid was synthesized from 1,2-dimethoxybenzene by Friedel-Crafts reaction with ethyl oxalyl monochloride to give 3,4-dimethoxyphenylglyoxalic acid ethyl ester,which was subjected to Wolff-Kishner-Huang reaction with an overall yield of about 64%.
作者 姚国新 陈刚 卢勇 朱锦桃
机构地区 浙江理工大学化学系 杭州迈可医药科技有限公司
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2010年第10期730-731,共2页 Chinese Journal of Pharmaceuticals
关键词 苯乙酸 合成 工艺 抗心律失常药 氧 维拉帕米 异喹啉类 Β受体 3 4-dimethoxyphenylacetic acid bevantolol verapamil intermediate preparation
分类号 O625.511 [理学—有机化学]
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参考文献7

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共引文献7

同被引文献58

引证文献3

二级引证文献3

中国医药工业杂志
2010年 第10期

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