摘要
目的:探讨辅酶Q_(10)联合还原型谷胱甘肽对肿瘤常规放射治疗患者的保护作用。方法:采用随机对照方法,将960例胸部恶性肿瘤放疗患者随机分为三组:A组为实验组,口服辅酶Q_(10),60mg/d;同时应用还原型谷胱甘肽钠,1.2g/d,静脉滴注,每日1次。B、C组为对照组,B组应用还原型谷胱甘肽钠,1.2g/d,静脉滴注,每日1次;C组为空白对照组。分析并比较三组的白细胞下降、放射性食管炎及放射性肺炎的发生率差异。结果:白细胞下降方面,三组间比较,差异均无统计学意义(均P>0.05)。放射性食管炎方面,B组与A、C组比较,差异均无统计学意义(均P>0.05);A组与C组比较,差异有统计学意义(P<0.05)。放射性肺炎方面,B组与A、C组比较,差异均无统计学意义(均P>0.05);A组与C组比较,差异有统计学意义(P<0.05)。结论:辅酶Q_(10)联合还原型谷胱甘肽对肿瘤常规放射治疗患者有保护作用,值得临床推广使用。
Objective：To discuss the protection of coenzyme Q10 combined reduced glutathione for the patients with conventional radiotherapy.Methods：960 cases of breast cancer patients receiving radiotherapy were randomly divided into 3groups according to random controlled method,group A was the experiment group,oral administration of coenzyme Q10,60 mg/d;at the same time take reduced glutathione sodium,1.2 g/d,intravenous infusion,once a day.Group B and groupC for the control groups,group B take reduced glutathione sodium,1.2 g/d,intravenous infusion,once a day;group C wasthe blank control group.The incidence rates of leukopenia,radiation esophagitis and radiation pneumonitis in three groupswere compared.Results：There was no significant difference in three groups on the leucopenia（all P〈0.05）.There was nosignificant difference in group B compared with group A,C（all P〈0.05）,and there was a significant difference betweengroup A and C（P〈0.05） on the radiation esophagitis and radiation pneumonitis respectively.Conclusion：Coenzyme Q10combined reduced glutathione sodium has a protective effect for the cancer patients treated with conventional radiation,soit is worthy of clinical use.
出处
《中国医药导报》
CAS
2010年第30期30-31,共2页
China Medical Herald
